Analysis of risk factors for Alzheimer’s disease in patients with and without normal tension glaucoma
| Predictive variables | Univariate analysis | Multivariate analysis | ||
| Unadjusted HR (95% CI) | P values | Adjusted HR (95% CI) | P values | |
| NTG (yes vs no) | 1.66 (1.55 to 1.79) | <0.0001 | 1.52 (1.41 to 1.63) | <0.0001 |
| Age | ||||
| <55 | Reference | Reference | ||
| 55–65 | 5.40 (4.30 to 6.78) | <0.0001 | 4.97 (3.95 to 6.24) | 0.0002 |
| 65–75 | 20.25 (16.45 to 24.94) | <0.0001 | 17.33 (14.02 to 21.42) | <0.0001 |
| ≥75 | 47.85 (38.92 to 58.82) | <0.0001 | 38.85 (31.43 to 48.02) | <0.0001 |
| Gender (male vs female) | 0.81 (0.76 to 0.87) | <0.0001 | 0.92 (0.86 to 0.98) | 0.01 |
| Comorbidities | ||||
| Diabetes | 1.56 (1.45 to 1.66) | <0.0001 | 1.05 (0.98 to 1.13) | 0.20 |
| Hypertension | 2.98 (2.74 to 3.23) | <0.0001 | 1.07 (0.97 to 1.17) | 0.17 |
| Hyperlipidaemia | 1.30 (1.21 to 1.39) | <0.0001 | 1.01 (0.94 to 1.09) | 0.79 |
| Coronary artery disease | 2.27 (2.13 to 2.42) | <0.0001 | 1.06 (0.99 to 1.14) | 0.10 |
| Stroke | 3.39 (3.16 to 3.64) | <0.0001 | 1.73 (1.61 to 1.87) | <0.0001 |
NTG, normal tension glaucoma.
In the multivariate analysis, all the other variables listed in the table were included for adjustment.