Table 4

Analysis of risk factors for AD among patients with normal tension glaucoma

Univariate analysisMultivariate analysis
Predictive variablesUnadjusted HRP valuesAdjusted HRP values
(95% CI)(95% CI)
Age
 <55ReferenceReference
  55–655.14 (3.48 to 7.59)<0.00014.74 (3.20 to 7.02)<0.0001
  65–7514.65 (10.20 to 21.04)<0.000112.83 (8.85 to 18.60)<0.0001
 ≥7534.06 (23.83 to 48.68)<0.000129.01 (20.04 to 42.00)<0.0001
Gender (male vs female)0.93 (0.83 to 1.06)0.280.81 (0.71 to 0.92)0.0009
Comorbidities
  Diabetes1.36 (1.20 to 1.54)<0.00011.01 (0.88 to 1.15)0.91
  Hypertension2.99 (2.54 to 3.52)<0.00011.11 (0.93 to 1.32)0.27
  Hyperlipidaemia1.21 (1.07 to 1.37)0.0021.08 (0.95 to 1.23)0.23
  Coronary artery disease2.21 (1.95 to 2.50)<0.00011.14 (0.99 to 1.30)0.06
  Stroke2.55 (2.21 to 2.94)<0.00011.38 (1.19 to 1.60)<0.0001
Types of glaucoma eye drops
 α-agonist (yes vs no)1.42 (1.20 to 1.69)<0.00010.93 (0.82 to 1.06)0.25
 Carbonic anhydrase inhibitors (yes vs no)0.80 (0.61 to 1.04)0.090.89 (0.74 to 1.06)0.19
 β-blocker (yes vs no)1.19 (0.83 to 1.69)0.340.85 (0.70 to 1.04)0.12
 Parasympathomimetics (pilocarpine)1.26 (0.52 to 3.02)0.610.96 (0.68 to 1.36)0.83
 Prostaglandin analogues (yes vs no)1.03 (0.88 to 1.21)0.721.07 (0.93 to 1.23)0.37
  • In the multivariate analysis, all the other variables listed in the table were included for adjustment.