Multivariable prediction model of incident depression during 2-year follow-up
| Predictor | RC | OR | 95% CI | P value |
| Female sex | – | – | – | |
| Age | – | – | – | |
| Somatic disorder | – | – | – | |
| DM2 | ||||
| CHD | ||||
| DM2 and CHD | ||||
| History of depression | – | – | – | |
| Baseline depression scores | 0.32 p.p.i. | 1.37 | 1.20 to 1.55 | 0.00 |
| Baseline anxiety scores | 0.12 p.p.i. | 1.13 | 1.02 to 1.25 | 0.01 |
| Stressful life event in past year | 0.74 | 2.10 | 1.02 to 4.32 | 0.04 |
| >3 chronic illnesses | 0.78 | 2.19 | 1.12 to 4.25 | 0.02 |
| Randomisation status I versus C | 0.14 | 1.15 | 0.58 to 2.29 | 0.68 |
An OR >1 reflects a higher probability the outcome an incident depression and an OR <1 reflects a lower probability compared with the reference category. OR estimated after multiple imputation (n=25 data sets) with p value of 0.157. Linear predictor corrected after bootstrapping=−4.1147 + 0.131*Randomisation status+0.7167*>3 chronic illnesses+0.680*stressful life event in past year+0.1118*baseline anxiety scores+0.2868*baseline depression scores.
CHD, coronary heart disease; DM2, diabetes mellitus type 2; p.p.i., per point increase; RC, regression coefficient.