Outcome measures assessed at follow-up baseline
| Composite outcomes | ACR20/50/70 (at least 20%/50%/70% improvement in ACR response criteria) MDA (% achieving minimal disease activity) Δ CDAI Δ DAS28 |
| Clinical outcomes | Δ No. of tender and swollen joints Δ CRP level Δ Physician’s global assessment (VAS global) |
| Patient-reported outcomes | Δ VAS-fatigue, Δ VAS-pain, pain detect score, Δ Patient VAS-global Δ Patient Value (composite score 0–100 mm of patient prioritised outcome measures questionnaire) Δ EQ-5D (VAS) Δ Well-being Δ Health Δ HAQ-MD Trans-Q |
ACR, American College of Rheumatology response criteria; CDAI, Clinical Disease Activity Index; CRP, C reactive protein; DAS28, Disease Activity Score 28; EQ-5D, based on the VAS scoring in the five domains; HAQ-MD Multi-Dimensional Health Assessment Questionnaire disability index (including visual analogue scale for pain and global); Trans-Q, Transition score; VAS, visual analogue scale.