Visit 1 Baseline | Visit 2 Chartis measurement | Visit 3 Admission for procedure | Visit 4 1 month safety phone call | Visit 5 3 months’ follow-up | 6 months | 9 months | Visit 6 1 year follow-up | |
History, physical exam | x | x | ||||||
Informed consent | x | |||||||
FFM | x | x | ||||||
MRC score | x | x | x | |||||
CAT score | x | x | x | |||||
Full pulmonary function* | x | x | x | |||||
CT thorax | x | x | ||||||
iSWT | x | x | x | |||||
Activity monitor given for 7 days | x | x (7 days prior to visit) | ||||||
Activity monitor collected | x | x | ||||||
c-PPAC score | x | x | ||||||
Bronchoscopy with Chartis measurement of collateral ventilation | x | |||||||
Randomisation | x | |||||||
Treatment intervention: LVRS or BLVR | x | |||||||
Health resource utilisation (CSRI questionnaire) | x | x | x | x |
*Spirometry, gas transfer, plethysmographic lung volumes, capillary blood gases.
BLVR, bronchoscopic lung volume reduction; CAT, COPD Assessment Test; c-PPAC, clinical visit version of the PROactive Physical Activty for COPD instrument; CSRI, Client Sociodemographic and Service Receipt Inventory; FFM, fat-free mass; iSWT, incremental shuttle walk test; LVRS, lung volume reduction surgery; MRC, Medical Research Council.