Table 2

Study timeline of the COSMOTB

Enrolment2 weeks4 weeks2 months4 months6 months9 months
ConsentX
Medical historyXXXXXXX
Physical examinationXXXXXXX
Xpert MTB/RIFX
AFB smearXXXXX
AFB cultureXXXXX
Drug-susceptibility testingCulture-based phenotypic DST and MTBDRplus will be performed on samples positive for mycobacterium.
Chest image testingXXXXXXX
HIV, HBV, HCVX
Complete blood countXXXXX
Blood chemistryXXXXX
Specimen collectionXXXX
  • AFB, acid-fast bacilli; DST, drug-susceptibility testing; HBV, hepatitis B virus; HCV, hepatitis C virus.