Subgroup analysis of the risk of serious ventricular arrhythmia associated with oral fluoroquinolones assessed in this study compared with cefixime for 1–7 days after the index date
| Cefixime | Ciprofloxacin | Levofloxacin | Ofloxacin | Moxifloxacin | |
| History of cardiovascular disease | |||||
| OR (95% CI) (IPTW) | Reference | 0.61 (0.34 to 1.08) | 0.96 (0.58 to 1.57) | 0.47 (0.24 to 0.85) | 2.36 (1.17 to 5.12) |
| Without cardiovascular disease | |||||
| OR (95% CI) (IPTW) | Reference | 0.79 (0.47 to 1.33) | 0.86 (0.54 to 1.34) | 0.36 (0.21 to 0.60) | 1.63 (0.84 to 3.29) |
| Age ≥65 | |||||
| OR (95% CI) (IPTW) | Reference | 0.78 (0.48 to 1.24) | 1.06 (0.71 to 1.60) | 0.36 (0.22 to 0.57) | 2.04 (1.16 to 3.73) |
| Age<65 | |||||
| OR (95% CI) (IPTW) | Reference | 0.64 (0.32 to 1.25) | 0.96 (0.51 to 1.81) | 0.84 (0.38 to 1.85) | 1.59 (0.60 to 4.58) |
| Male | |||||
| OR (95% CI) (IPTW) | Reference | 0.61 (0.36 to 0.99) | 0.82 (0.53 to 1.25) | 0.53 (0.29 to 0.96) | 1.91 (1.00 to 3.80) |
| Female | |||||
| OR (95% CI) (IPTW) | Reference | 0.62 (0.35 to 1.07) | 0.89 (0.54 to 1.46) | 0.33 (0.19 to 0.56) | 1.79 (0.87 to 3.92) |
IPTW, inverse probability of treatment weighting.