Table 1

On treatment schedule with dose modifications 

DayTimeDoseDose titrationMaximum dose per 24-hour period
-1ManeOne capsuleNAFive capsules
12.5mg THC/CBD or placebo
Midi
(at least 4 hours after previous dose)
Two capsulesMiss dose if intoxicated
Nocte
(at least 4 hours after previous dose)
One to two capsulesMiss dose if intoxicated
Reduce dose by one capsule if previous dose not tolerated
Maitain dose if previous dose tolerated
160 min prior to chemotherapyOne to two capsulesMiss dose if intoxicated
Reduce dose by one capsule if previous dose not tolerated
Miss dose if previous dose tolerated
Increase dose by one capsule if previous dose tolerated, but inadequate nausea control
Eight capsules
20mg THC/CBD or placebo
Immediately after completion of day 1 chemotherapy infusionOne to three capsules
4 hours after completion of day 1 chemotherapy infusionOne to three capsules
2Continue three times a day
Mane
One to four capsulesMiss dose if intoxicated
Reduce dose by one capsule if previous dose not tolerated
Maintain dose if previous dose tolerated
Increase dose by one capsule if previous dose tolerated, but inadequate nausea control
Twelve capsules
30mg THC/CBD or placebo
3Midi
4Nocte
5Mane
Midi (final dose)
One to four capsulesMiss dose if intoxicated
Reduce dose by one capsule if previous dose not tolerated
Maintain dose if previous dose tolerated
Increase dose by one capsule if previous dose tolerated, but inadequate nausea control
Eight capsules
20mg THC/CBD or placebo
  • Table 1 shows the starting dose will be one capsule PO on the morning of day −1, with the next scheduled dose of two capsules (if tolerated, at midday), followed by two capsules that evening (if tolerated). On day 1, subjects receive one to two capsules 60 min prior to chemotherapy infusion, followed by one to three capsules immediately after completion of day 1 infusional chemotherapy, then one to three capsules 4 hours after completion of day 1 infusional chemotherapy. On days 2–5, subjects take one to four tablets three times a day, with instruction to dose titrate according to intoxication, tolerance of prior dose and nausea control. The final dose is at midday on day 5, with no further treatment until day −1 of the next chemotherapy cycle.

  • CBD, cannabidiol; NA, not applicable; TCH, tetrahydrocannabinol.