Table 1

Schedule of procedures, interventions and assessments

	Screening	Registration	V¹		V²		V³		V⁴
				T^1–3		4–5 Week		T^4–6
				(Telephone)		(Washout)		(Telephone)
Agreement	○
Registration		○
Assignment		○
Prescription			○				○
Collect leftover medicine					○				○
Daily medication diary			○				○
Grip power	○		○		○		○		○
Pinch power			○		○		○		○
10 s grip and release test			○		○		○		○
Tongue pressure			○		○		○		○
mQMG score			○		○		○		○
Timed walk test			○		○		○		○
Peripheral nerve conduction studies			○		○		○		○
Blood examination*	○		○		○		○		○
ECG	○		○		○		○		○
DXA		○
Respiratory function test			○		○		○		○
ALSFRS-R			○		○		○		○
SBMAFRS			○		○		○		○
SF-36			○		○		○		○
INQoL			○		○		○		○
IVR diary		○	○	○	○		○	○	○
Vital signs	○		○		○		○		○

*Complete blood count, electrolytes, creatinine, creatine kinase, aldolase, lactate dehydrogenase, aspartate aminotransferase, alanine aminotransferase, and testosterone.
ALSFRS-R, revised Amyotrophic Lateral Sclerosis Functional Rating Scale; DXA, dual-energy X-ray absorptiometry; INQoL, Individualised Neuromuscular Quality of Life questionnaire; IVR, interactive voice response; mQMG, Modified Quantitative Myasthenia Gravis; SBMAFRS, Spinal and Bulbar Muscular Atrophy Functional Rating Scale; SF-36, 36-Item Short Form Health Survey; V¹, intervention period 1; V ², intervention period 2; V³, intervention period 3; V⁴, intervention period 4.