Table 1

Study entry and exit criteria applied to potential participant records used in the study

Study entry criteriaStudy exit (first to occur)
Date of the third consecutive blood pressure reading between 140/90 and 159/99 mm Hg (within 12 months of each other)Last date at which the most recent linked data are available from the CPRD (study end date, September 2015)
Aged between 18 and 74 yearsDate of third consecutive blood pressure reading >160/100 mm Hg (within 12 months of each other) (progression to stage 2 hypertension)
Linked general practice, Hospital Episodes Statistics and Office for National Statistics mortality recordsDate of first record of a cardiovascular risk factor (left ventricular hypertrophy, atrial fibrillation, diabetes or chronic kidney disease or family history of premature heart disease) or high cardiovascular risk score (>20%)
Registered to a CPRD practice classified as ‘up-to-standard’Date of death
Classified as a CPRD ‘acceptable patient’Date of the most recent data upload from the practice to which a given patient is registered
No Read code for previous cardiovascular disease (stroke, myocardial infarction, angina, coronary heart disease, peripheral vascular disease, heart failure)Date at which a given patient transfers out of a registered CPRD practice
No Read code for cardiovascular risk factor (left ventricular hypertrophy, atrial fibrillation, diabetes or chronic kidney disease or family history of premature heart disease)Date of first coded lifestyle advice given after study entry (lifestyle advice analysis only)
No record of any blood pressure lowering medication prescription in the 12 months prior to the third consecutive blood pressure reading between 140/90 and 159/99 mm HgDate of first prescribed antihypertensive treatment given after study entry (treatment analysis only)
  • CPRD, Clinical Practice Research Datalink.