Table 1

CYCLE pilot RCT schedule of enrolment, interventions and assessments

	Study period
	Enrolment	Allocation	Postallocation				Close out
Time point	ICU admission	0	In ICU	ICU awakening	ICU discharge	Hospital discharge	Close out
Enrolment
Eligibility screening	X
Informed consent	X
Allocation		X
Interventions
In-bed cycling+routine PT			X	X	X
Routine PT			X	X	X
Assessments
Severity of illness: APACHE II	X
Charlson comorbidity index56	X
Functional comorbidity index57	X
Clinical Frailty Scale43	X				X	X
Function: Katz activities of daily living scale44	X				X	X
Physical strength and function*				X	X	X (blinded)
Psychological distress: Intensive Care Psychological Assessment Tool45				X
Quality of life: Euro-QOL 5DL47 48					X	X
ICU and hospital length of stay						X	X
Mortality					X	X	X

In this table, we outline patient enrolment, interventions and assessments in the CYCLE pilot RCT.
*Strength and function assessments at ICU awakening include Physical Function ICU Test (scored),31 ,32 Medical Research Council Sum Score34 ,35 and 30 s sit-to-stand test;37 ,38 at ICU discharge and hospital discharge, includes all ICU awakening assessments plus the 2 min walk test39 ,40 and quadriceps strength with hand-held dynamometry.36
ICU, intensive care unit; PT, physiotherapy; RCT, randomised clinical trial.