Table 4

Incremental cost-effectiveness of 10TT versus usual care

Incremental costIncremental QALYsIncremental net monetary benefitProbability of being cost-effective (%)
Mean (£)(95% CI)Mean(95% CI)£20 000(95% CI)£30 000(95% CI)£20 000£30 000
Mean (£)Mean (£)
Base case*−36(−512 to 441)0.001(−0.080 to 0.082)49(−1709 to 1800)55(−2489 to 2583)5252
Base case with control group intervention cost†−122(−598 to 353)0.001(−0.080 to 0.082)140(−1666 to 1902)148(−2463 to 2693)5654
Complete case analysis‡−66(−907 to 774)−0.047(−0.180 to 0.086)−889(−3993 to 2253)−1361(−5772 to 3052)2928
Primary and secondary care costs increased§−40(−556 to 475)0.001(−0.080 to 0.081)48(−1743 to 1851)53(−2520 to 2623)5251
Drug costs increased§23(−396 to 442)0.001(−0.080 to 0.077)−14(−1734 to 1716)−9(−2511 to 2510)4950
All costs increased§−39(−554 to 476)0.001(−0.080 to 0.082)43(−1756 to 1851)46(−2537 to 2641)5251
Primary and secondary care costs decreased¶−31(−463 to 401)0.001(−0.080 to 0.081)54(−1683 to 1804)64(−2453 to 2587)5252
Drug costs decreased¶26(−387 to 438)0.001(−0.080 to 0.081)0(−1741 to 1727)11(−2530 to 2520)5051
All costs decreased¶−32(−460 to 395)0.001(−0.080 to 0.081)50(−1682 to 1811)59(−2458 to 2599)5252
  • *n=537. Data include values imputed using multiple imputation (see text). The 95% CIs were derived from 1000 bootstrap replications of each of the 20 imputed data sets (see text). The incremental net monetary benefit and the probability 10TT is cost-effective are based on the QALYs gained and incremental costs and calculated at a maximum willingness to pay for a QALY of £20 000 and £30 000.

  • †As for the base case analysis. Standard weight-loss interventions (Weight Watchers, Slimming World, Size Down Programme) are included in the control group.

  • ‡As for the base case analysis. No multiple imputation of missing values and the 95% CIs were derived from 1000 bootstrap replications of a single data set containing the n=72 participants in the 10TT group and n=91 participants in the usual care group with no missing values. The costs of interventions in the control group (Weight Watchers, Slimming World, Size Down Programme) were excluded.

  • §As for the base case analysis. Costs were increased by 10% for 10TT.

  • ¶As for the base case analysis. Costs were decreased by 10% for 10TT.

  • 10TT, Ten Top Tips; QALYs, quality-adjusted life years.