Table 3

Adverse and serious adverse events in aspirin and non-aspirin taking groups

EventAspirin, n=192Non-aspirin, n=354OR (95% CI)
Adverse events
 Adverse events, N1231432.6 (1.8 to 3.8)
 Vaginal spotting, n (%)29 (15.1)28 (7.9)2.1 (1.2 to 3.6)
 Postpartum haemorrhage, n (%)
  > 500 mL26 (13.5)20 (5.6)2.6 (1.4 to 4.8)
  >1000 mL7 (3.6)5 (1.4)2.8 (0.9 to 9.0)
  Blood transfusion340.5 (0.1 to 2.7)
  Hb drop < 8 g/dL470.3 (0.1 to 1.4)
Serious adverse event
 NICU admission
  Sepsis32
  Hypoglycaemia01
  Prematurity14
  Jaundice11
  Persistently low Apgar13
  TTN13
  Meconium aspiration10
  Hypoxic ischaemic encephalopathy11
  Very low birth weight01
 Total9161.04 (0.45 to 2.40)
 Perinatal death24
 Total240.92 (0.17 to 5.10)
 Maternal admission
  Preterm labour32
  Pre-eclampsia87
  Antepartum haemorrhage37
  PPROM02
  Fetal compromise12
  Infection25
  Other41
 Total21261.55 (0.85 to 2.83)
 Congenital anomaly
  Cardiac12
  Gastrointestinal32
  Neurological01
  Renal01
 Total461.23 (0.34 to 4.43)
 Total serious adverse events36521.34 (0.84 to 2.14)
  • There may be >1 adverse event or serious adverse event per subject.

  • Very low birth weight ≤1500 g.

  • Hb, haemoglobin; NICU, neonatal intensive care unit; PPROM, preterm premature rupture of membranes; TTN, transient tachypnoea of the newborn