HRs for rheumatoid arthritis in the propensity score-matched HCV cohort
| Variable | Crude | Adjusted* | ||||
| HR | 95% CI | P values | HR | 95% CI | P values | |
| HCV cohort | ||||||
| Untreated | 1 | Reference | 1 | Reference | ||
| Treated with IBT | 0.63 | 0.42 to 0.93 | 0.019 | 0.63 | 0.43 to 0.94 | 0.023 |
| Sex (men/women) | 0.45 | 0.36 to 0.57 | <0.001 | 0.49 | 0.38 to 0.62 | <0.001 |
| Age (per year) | 1.02 | 1.01 to 1.03 | <0.001 | 1.01 | 1.00 to 1.02 | 0.013 |
| Comorbidities (yes/no) | ||||||
| Diabetes | 1.20 | 0.95 to 1.52 | 0.13 | 1.03 | 0.79 to 1.36 | 0.81 |
| COPD | 1.37 | 1.09 to 1.72 | 0.006 | 1.18 | 0.92 to 1.52 | 0.20 |
| Periodontitis | 0.80 | 0.62 to 1.02 | 0.08 | 0.79 | 0.61 to 1.02 | 0.07 |
| Geographic region | ||||||
| Northern | 1 | Reference | 1 | Reference | ||
| Central | 1.34 | 1.00 to 1.78 | 0.048 | 1.36 | 0.98 to 1.88 | 0.07 |
| Eastern | 2.19 | 1.26 to 3.79 | 0.005 | 2.05 | 1.14 to 3.67 | 0.016 |
| Southern | 1.04 | 0.78 to 1.39 | 0.77 | 1.01 | 0.74 to 1.38 | 0.95 |
| Urbanisation level | ||||||
| Urban | 1 | Reference | 1 | Reference | ||
| Suburban | 1.11 | 0.83 to 1.49 | 0.49 | 0.10 | 0.73 to 1.37 | 0.98 |
| Rural | 1.20 | 0.88 to 1.64 | 0.24 | 0.96 | 0.67 to 1.39 | 0.83 |
| Enrolee category | ||||||
| 1 | 1 | Reference | 1 | Reference | ||
| 2 | 1.11 | 0.48 to 2.52 | 0.81 | 0.71 | 0.39 to 1.29 | 0.26 |
| 3 | 1.14 | 0.88 to 1.47 | 0.33 | 0.90 | 0.60 to 1.32 | 0.60 |
| 4 | 1.32 | 0.95 to 1.84 | 0.10 | 1.07 | 0.77 to 1.50 | 0.68 |
| Number of medical visits | 1.01 | 1.01 to 1.01 | <0.0001 | 1.01 | 1.00 to 1.01 | 0.005 |
| Charlson comorbidity index | 1.06 | 1.00 to 1.11 | 0.033 | 0.99 | 0.92 to 1.06 | 0.77 |
*Adjusted for age per year, sex, comorbidities, geographic region, urbanisation level, enrolee category, number of medical visits and Charlson comorbidity index.
COPD, chronic obstructive pulmonary disease; HCV, hepatitis C virus; IBT, interferon-based therapy.