Hand-foot syndrome grading scale* (modified from13)
| Grade | Clinical domain† | Functional domain |
| 1 | Numbness, dysesthesia/paresthesia, tingling, painless swelling or erythema. | Discomfort that does not disrupt normal activities. |
| 2 | Painful erythema with swelling. | Discomfort that affects activities of daily living. |
| 3 | Moist desquamation, ulceration, blistering and severe pain. | Severe discomfort, unable to work or perform activities of daily living. |
*This scale applies only for the grading of hand-foot syndrome and not for any other skin abnormalities and/or other cutaneous areas.
†In the case of a discrepancy between clinical and functional domains, the assigned grade will be the higher of the grades.