Table 1

Hand-foot syndrome grading scale* (modified from13)

GradeClinical domain†Functional domain
1Numbness, dysesthesia/paresthesia, tingling, painless swelling or erythema.Discomfort that does not disrupt normal activities.
2Painful erythema with swelling.Discomfort that affects activities of daily living.
3Moist desquamation, ulceration, blistering and severe pain.Severe discomfort, unable to work or perform activities of daily living.
  • *This scale applies only for the grading of hand-foot syndrome and not for any other skin abnormalities and/or other cutaneous areas.

  • †In the case of a discrepancy between clinical and functional domains, the assigned grade will be the higher of the grades.