Table 2

Incidence and HRs of keloid by demographic characteristics and concurrent allergic disease or comorbidity among patients with or without atopic dermatitis

VariablesPatients with atopic dermatitisPatients without atopic dermatitisCompared with non-atopic dermatitis
KeloidPYsRateKeloidPYsRateCrude HR (95% CI)Adjusted HR* (95% CI)Adjusted HR† (95% CI)
Overall16350 990.853.19532499087.751.073.84 (3.17 to 4.66)‡3.80 (3.14 to 4.61)‡3.19 (2.60 to 3.89)‡
Gender
  Men4717 992.052.61123176032.980.694.81 (3.31 to 6.99)‡4.72 (3.24 to 6.85)‡3.67 (2.47 to 5.44)‡
  Women11632 998.803.52409323054.761.273.56 (2.84 to 4.45)‡3.53 (2.82 to 4.42)‡3.03 (2.39 to 3.83)‡
Stratify by age (years)
 <4012226 311.814.647563 234.611.194.07 (3.27 to 5.07)‡4.07 (3.27 to 5.08)‡3.44 (2.74 to 4.31)‡
 40–593015 707.991.912938 829.760.753.31 (2.19 to 4.99)‡3.32 (2.20 to 4.99)‡2.74 (1.79 to 4.17)‡
> 60118971.061.231122 791.710.482.87 (1.49-5.56)§2.82 (1.46-5.44)§2.36 (1.22-4.59)¶
Concurrent allergic disease**
 No229661.482.28139194784.110.715.41 (4.02 to 7.27)‡4.03 (2.55 to 6.37)‡4.41 (3.27 to 5.94)‡
 Yes14141 329.373.41393304303.641.293.19 (2.52 to 4.05)‡3.34 (2.72 to 4.12)‡2.62 (2.05 to 3.34)‡
Comorbidity††
 No5914 141.344.17247246626.441.004.13 (2.62 to 6.52)‡4.85 (3.61 to 6.52)‡3.78 (2.38 to 5.98)‡
 Yes10436 849.512.82285252461.311.123.37 (2.74 to 4.15)‡2.82 (2.22 to 3.58)‡3.08 (2.48 to 3.82)‡
  • *Model adjusted for age and gender.

  • †Model adjusted for age, gender, urbanisation, concurrent allergic diseases (asthma, allergic rhinitis and allergic conjunctivitis)and relevant comorbidities (hypertension, diabetes mellitus, hyperlipidaemia, chronic kidney diseases, chronic liver disease, chronic obstructive pulmonary disease, stroke, coronary artery disease, mental disorders and alcohol attributed disease).

  • ‡P<0.001.

  • §P=0.002.

  • ¶P=0.011.

  • **Patients with any concurrent allergic disease, including asthma, allergic rhinitis and allergic conjunctivitis, were classified as the allergic disease group.

  • ††Patients with any examined comorbidities, including hypertension, diabetes mellitus, hyperlipidaemia, chronic kidney diseases, chronic liver disease, chronic obstructive pulmonary disease, stroke, coronary artery disease, mental disorders and alcohol attributed disease, were classified as the comorbidity group.

  • PYs, person-years; rate, incidence rate in per 1000 person-years.