Variables | Patients with atopic dermatitis | Patients without atopic dermatitis | Compared with non-atopic dermatitis | ||||||
Keloid | PYs | Rate | Keloid | PYs | Rate | Crude HR (95% CI) | Adjusted HR* (95% CI) | Adjusted HR† (95% CI) | |
Overall | 163 | 50 990.85 | 3.19 | 532 | 499087.75 | 1.07 | 3.84 (3.17 to 4.66)‡ | 3.80 (3.14 to 4.61)‡ | 3.19 (2.60 to 3.89)‡ |
Gender | |||||||||
Men | 47 | 17 992.05 | 2.61 | 123 | 176032.98 | 0.69 | 4.81 (3.31 to 6.99)‡ | 4.72 (3.24 to 6.85)‡ | 3.67 (2.47 to 5.44)‡ |
Women | 116 | 32 998.80 | 3.52 | 409 | 323054.76 | 1.27 | 3.56 (2.84 to 4.45)‡ | 3.53 (2.82 to 4.42)‡ | 3.03 (2.39 to 3.83)‡ |
Stratify by age (years) | |||||||||
<40 | 122 | 26 311.81 | 4.64 | 75 | 63 234.61 | 1.19 | 4.07 (3.27 to 5.07)‡ | 4.07 (3.27 to 5.08)‡ | 3.44 (2.74 to 4.31)‡ |
40–59 | 30 | 15 707.99 | 1.91 | 29 | 38 829.76 | 0.75 | 3.31 (2.19 to 4.99)‡ | 3.32 (2.20 to 4.99)‡ | 2.74 (1.79 to 4.17)‡ |
> 60 | 11 | 8971.06 | 1.23 | 11 | 22 791.71 | 0.48 | 2.87 (1.49-5.56)§ | 2.82 (1.46-5.44)§ | 2.36 (1.22-4.59)¶ |
Concurrent allergic disease** | |||||||||
No | 22 | 9661.48 | 2.28 | 139 | 194784.11 | 0.71 | 5.41 (4.02 to 7.27)‡ | 4.03 (2.55 to 6.37)‡ | 4.41 (3.27 to 5.94)‡ |
Yes | 141 | 41 329.37 | 3.41 | 393 | 304303.64 | 1.29 | 3.19 (2.52 to 4.05)‡ | 3.34 (2.72 to 4.12)‡ | 2.62 (2.05 to 3.34)‡ |
Comorbidity†† | |||||||||
No | 59 | 14 141.34 | 4.17 | 247 | 246626.44 | 1.00 | 4.13 (2.62 to 6.52)‡ | 4.85 (3.61 to 6.52)‡ | 3.78 (2.38 to 5.98)‡ |
Yes | 104 | 36 849.51 | 2.82 | 285 | 252461.31 | 1.12 | 3.37 (2.74 to 4.15)‡ | 2.82 (2.22 to 3.58)‡ | 3.08 (2.48 to 3.82)‡ |
*Model adjusted for age and gender.
†Model adjusted for age, gender, urbanisation, concurrent allergic diseases (asthma, allergic rhinitis and allergic conjunctivitis)and relevant comorbidities (hypertension, diabetes mellitus, hyperlipidaemia, chronic kidney diseases, chronic liver disease, chronic obstructive pulmonary disease, stroke, coronary artery disease, mental disorders and alcohol attributed disease).
‡P<0.001.
§P=0.002.
¶P=0.011.
**Patients with any concurrent allergic disease, including asthma, allergic rhinitis and allergic conjunctivitis, were classified as the allergic disease group.
††Patients with any examined comorbidities, including hypertension, diabetes mellitus, hyperlipidaemia, chronic kidney diseases, chronic liver disease, chronic obstructive pulmonary disease, stroke, coronary artery disease, mental disorders and alcohol attributed disease, were classified as the comorbidity group.
PYs, person-years; rate, incidence rate in per 1000 person-years.