Table 3

Nephrotic syndrome accompanied with different amounts of comorbidities all increased the incidence and HR of Parkinson’s disease and secondary parkinsonism

VariableNephrotic syndromeCrude HR
(95% CI)
Adjusted HR
(95% CI)
YesNo
EventPYRateEventPYRate
Number of comorbidities†
0911 9670.753562 2510.561.34 (1.13 to 1.58)***1.66 (1.43 to 1.94)***
11049172.032616 5351.571.29 (1.01 to 1.66)*1.63 (1.28 to 2.08)***
2+3974505.238418 2784.601.14 (0.94 to 1.38)1.35 (1.12 to 1.63)**
  • †Patients with any one of the comorbidities (diabetes, hypertension, hyperlipidaemia, coronary artery disease, head injury, COPD, depression, stroke, dementia and epilepsy).

  • Adjusted HR, HR adjusted for age and immunosuppressant therapy and the biological therapy rituximab with prednisolone; crude HR, relative HR; PY, person-years; rate, incidence rate per 1000 person-years. 

  • * P < .05, ** P < .01, *** P < .001