Nephrotic syndrome accompanied with different amounts of comorbidities all increased the incidence and HR of Parkinson’s disease and secondary parkinsonism
| Variable | Nephrotic syndrome | Crude HR (95% CI) | Adjusted HR (95% CI) | |||||
| Yes | No | |||||||
| Event | PY | Rate | Event | PY | Rate | |||
| Number of comorbidities† | ||||||||
| 0 | 9 | 11 967 | 0.75 | 35 | 62 251 | 0.56 | 1.34 (1.13 to 1.58)*** | 1.66 (1.43 to 1.94)*** |
| 1 | 10 | 4917 | 2.03 | 26 | 16 535 | 1.57 | 1.29 (1.01 to 1.66)* | 1.63 (1.28 to 2.08)*** |
| 2+ | 39 | 7450 | 5.23 | 84 | 18 278 | 4.60 | 1.14 (0.94 to 1.38) | 1.35 (1.12 to 1.63)** |
†Patients with any one of the comorbidities (diabetes, hypertension, hyperlipidaemia, coronary artery disease, head injury, COPD, depression, stroke, dementia and epilepsy).
Adjusted HR, HR adjusted for age and immunosuppressant therapy and the biological therapy rituximab with prednisolone; crude HR, relative HR; PY, person-years; rate, incidence rate per 1000 person-years.
* P < .05, ** P < .01, *** P < .001