Symptoms and date definitions
| Symptoms used | Onset of first symptom | Date of first presentation in healthcare services | Date of first referral | Date of diagnosis |
| Friese et al 8 (USA) | ||||
| Anaemia Packed red blood cell transfusion Back pain | NA | 1 year before diagnosis | NA | SEER cancer diagnosis date |
| Howell et al 31 (UK) | ||||
| Tiredness Pain Shortness of breath Infections Joint problems/fractures Stomach/bowel symptoms Other | Patient reported | Patient reported | NA | Date provided by the haematological malignancy Diagnostic service |
| Lyratzopoulos et al 26 (UK) | ||||
| Not reported | Estimated based on patient’s clinical records | 2 years before diagnosis | Date that the referral letter was sent | Clinical records and hospital correspondence |
| Varga et al 29 (Hungary) | ||||
| Bone symptoms Anaemia Renal failure General symptoms Other Tumour presence Metastatic bone disease | NA | 3 years before diagnosis | NA | Tertiary haematology centre |
| Neal et al 25 (UK) | ||||
| Bleeding Bone pain Bruising Anaemia Fatigue Anorexia Weight loss | NA | 1 year before diagnosis | NA | First occurrence of a myeloma Read Code in the patient’s record in CPRD database |
| Din et al 24 (UK) | ||||
| Bleeding Bone pain Bruising Anaemia Fatigue Anorexia Weight loss | NA | 1 year before diagnosis | NA | First occurrence of a myeloma Read Code in the patient’s record in CPRD database |
| Lyratzopoulos et al 27 (UK) | ||||
| Not reported | NA | 2 years before diagnosis | Date that the referral letter was sent | Clinical records and hospital correspondence |
| Goldschmidt et al 30 (Israel)* | ||||
| Pain (back, cervical spine, musculoskeletal, non-specific) Infection Weight loss Fatigue Peripheral oedema Constipation Presyncope Syncope Dizziness | NA | 2 years before diagnosis | NA | Israel National Cancer Registry |
| Swann et al 28 (UK) | ||||
| Not reported | NA | 2 years before diagnosis | Date that the referral letter was sent | Hospital Episode Statistics |
| NA-Not applicable | ||||