Table 1

The timeline of the study

Intervention period
Days of antibiotic treatmentDays after antibiotic treatment
12345Every dayn (end of antibiotic treatment)n+1n+2n+3n+4n+5n+6n+7Close-out
 Eligibility assessmentx
 Informed consent receptionx
 Allocation and randomisationx
 Handing over of study diaryx
 Multistrain probiotic Embedded Image
 Placebo Embedded Image
Data collection
 Study diary Embedded Image
 Stool tests in case of diarrhoea Embedded Image
 Stool microbiota examinationxxxx
 Reception of study diary and unused productx