Review of studies evaluating impact of dialysis modality on kidney-transplant outcomes
| Authors (year),* country | Study design | Patient no | Follow-up period | Post-transplant outcomes | Favour | Quality† |
| Goldfarb-Rumyantzev et al (2005),41 USA | Cohort, retrospective database | 92 844 patients from USRDS database | 10 years (during 1990–1999) | PD was associated with shorter time on dialysis, better graft and patient survival | PD | Good |
| Molnar et al (2011),40 USA | Cohort, retrospective database | 14 508 recipients (HD:12416, PD:2092) | 6 years (during 2001–2006) | PD with lower mortality rate, but no differences in DGF or death-censored graft survival after adjustment | PD | Fair |
| Schwenger et al (2011),42 Germany | Cohort, multicentre | 57 315 recipients (HD: 45 651, PD: 11 664) | Median 5 years (during 1998–2007) | PD with lower all-cause mortality but similar graft survival | PD | Good |
| Kramer et al (2012),39 the Netherlands | Cohort, retrospective database | 29 088 adult recipients from 16 European renal registries | Median 5 years (during 1999–2008) | PD was associated with better patient and graft survivals, but no longer significant after instrumental variable analysis | Non | Good |
| López-Oliva et al (2013),12 Spain | Cohort, retrospective single-centre | 236 recipients (HD:118, PD:118) | Median 8.5 years (during 1990–2002) | PD has better long-term patient survival, but not graft survival in the multivariate analysis | PD | Fair |
| Martins et al (2015),11 Portugal | Cohort, retrospective single centre | 158 recipients of pancreas-kidney transplantation (HD:119, PD:39) | Median 5.9 years (during 2000–2013) | PD with more intra-abdominal infection, leading to pancreas loss and renal thrombosis, with adverse impact on patient survival | HD | Fair |
| Dipalma et al (2016),14 Spain | Cohort, retrospective single centre | 180 donor-matched recipients (HD:80, PD:80) | Median 73 months (during 1990–2007) | No significant difference in death-censored graft survival and patient survival after propensity-score adjustment | Non | Good |
| Tang et al (2016),13 China | Meta-analysis | 12 studies, excluded children, sample <100 pts | – | PD conferred less DGF, better 5-year patient survival, but not graft survival | PD | Fair |
*The references are listed in the order of published year.
†Quality assessments were based on the Newcastle-Ottawa Scale for observational cohort studies and the Preferred Reporting Items for Systematic Reviews and Meta-Analyses tool for systemic review/meta-analysis. All studies were rated as ‘good, fair or poor’ according to fulfilment of applied assessment checklist.
DGF, delayed graft function; HD, haemodialysis; PD, peritoneal dialysis; USRDS, United States Renal Data System.