Table 1

Evidence map of multiperson N-of-1 and repeated period crossover studies

DescriptionMulti-person N-of-1
studies (n=62)
Publication years1979–2017
SubjectsTotal N (median, IQR)
  Enrolled2153 (16, 9–42)
  Completed1705 (12, 7–32)
Intervention and comparisons
  Head-to-head active drugs10
  Placebo47
  Active drug and placebo1
Population
  Paediatric12
  Adults50
Major systems studied
  Arthritis/rheumatology10
  Cardiovascular3
  Gastrointestinal7
  Hypertension1
  Psychiatry9
  Neurology16
  Respiratory9
  Miscellaneous* 7
Top 5 disease conditions
  ADHD6
  Angina3
  Chronic pain5
  GORD5
  Obstructive airway6
  Osteoarthritis6
  • *Sleep disorders, allergy, cancer, muscular, vascular (for multiperson N-of-1); pain, urology, GYN, Heme/Onc, allergy, dermatology, drug abuse, endocrine, lipids, nephrology, ophthalmology, respiratory (for repeated crossover studies).

  • ADHD, attention-deficit hyperactivity disorder; GORD, gastro-oesophageal regurgitation disorder; n, number of participants.