Table 3

Characteristics of studies reporting person-level data

Author, YearDiseaseNumber enrolled (analysed)InterventionComparatorCross-over periodsTotal intervention durationOutcome measures per period
Studies with reanalysable person-level outcomes
Camfield, 1996Mental retardation with fragmented sleep6 (6)MelatoninPlacebo710 weeks14
Hinderer,
1990
Traumatic spinal cord injury5 (5)BaclofenPlacebo39 weeks2
Langer,
1993
Gastro-oesophageal reflux2 (2)CisapridePlacebo36 weeks5
Lashner,
1990
Ulcerative colitis7 (6)NicotinePlacebo48 weeks1
Maier,
1994
Chronic depression10 (9)SulpiridePlacebo428 weeks42
Mandelcorn, 2004Brain injury4 (4)OndansetronPlacebo45 weeks1
McQuay,
1994
Neuropathic pain19 (19)DextromethorphanPlacebo520 days1
Miyazaki, 1995Unstable angina22 (22)Isosorbide dinitrateIsosorbide dinitrate: intermittent injection39 days6
Nathan,
2006
Paediatric brain tumour12 (7)Ondansetron
and metopimazine
Ondansetron and placeboUnclear189 daysUnclear
Parodi,
1979
Unstable angina12 (12)VerapamilPlacebo410 daysUnclear
Parodi,
1986
Unstable angina10 (10)VerapamilPropranolol, placebo818 daysUnclear
Tison,
2012
Levodopa-induced dyskinesia in patients with Parkinson’s disease10 (10)SimvastatinPlacebo696 days1
Studies with re-analyzable person-level treatment effects
Emmanuel,
2012
Chronic intestinal pseudo-obstruction7 (4)PrucalopridePlacebo1648 weeks21
Haas,
2004
Chronic tension type and migraine headache39 (16)DextroamphetamineEqui-stimulatory caffeine820 days20
Jaeschke,
1991
Fibromyalgia22 (23)AmitriptylinePlacebo612 weeks2
Johannessen,
1992
Dyspepsia68 (46)CimetidinePlacebo12184 days15
Lipka,
2017
Autoimmune myasthenia gravis4 (4)EphedrinePlacebo46 weeks1
Mahon,
1996
Irreversible chronic airflow limitation16 (14)TheophyllinePlacebo873 days1
March,
1994
Osteoarthritis25 (15)DiclofenacParacetamol612 weeks14
Patel,
1991
Non-reversible chronic airflow limitation26 (18)Ipratropium bromide/theophylline
/salbutamol
/beclomethasone
Placebo66 weeksUnclear
Wallace,
1994
Attention deficit hyperactivity disorder11 (7)MethylphenidatePlacebo1414 days1
Woodfield,
2005
Skeletal muscle cramps13QuininePlacebo614 weeks2
Zucker,
2006
Fibromyalgia58Amitriptyline and placeboAmitriptyline and fluoxetine combination636 weeks1
Study with both person-level data
Pereira,
1995
Atrial fibrillation/deep venous thrombosis7Generic warfarinCoumadin1030 weeks2
Joy,
2014
Statin-related myalgia8 (7)StatinPlacebo633 weeks3
Study with insufficiently reported person-level data
Person-level outcome data
Denburg,
1994
Systemic lupus erythematosus10PrednisonePlacebo630 weeks1
Mitchel,
2015
Fatigue in advanced cancer43 (33)MethylphenidatePlacebo618 days6
Nikles,
2000
Osteoarthritis14IbuprofenParacetamol; placebo612 weeks14
Nikles,
2015
Dry mouth in advanced cancer17 (4)PilocarpinePlacebo618 days6
Nikles,
2017
Acquired brain injury53 (38)Nervous system stimulantsPlacebo618 days6
Reitberg,
2002
Allergic rhinitis36Loratadine and chlorpheniramine
maleate
loratadine with placebo832 days4
Sheather-Reid,
1998
Chronic pain8Ibuprofen/codeinePlacebo612 weeks14
Person-level treatment effects
Huber,
2007
Juvenile idiopathic arthritis6AmitriptylinePlacebo617 weeks12
Privitera,
1994
Partial seizure16DezinamidePlacebo635 weeks6
Wegman,
2003
Osteoarthritis13ParacetamolNon-steroidal anti-inflammatory drugs1020 weeks14
Wegman,
2005
Regular temazepam users15TemazepamPlacebo1010 weeks7