Table 3

Overall cumulative period of using SGAs

Period of SGA useCKD cases (n=3411)Controls
(n=10 233)
OR (95% CI)P valueAOR* (95% CI)P value
Cumulative SGA use
 Non-users303130411
 0<period≤ 901775521.38 (1.12 to 1.71)0.00261.20 (0.95 to 1.51)0.1247
 90<period≤ 180922411.65 (1.26 to 2.16)0.00031.42 (1.06 to 1.91)0.0208
 180<period≤ 100040912711.39 (1.17 to 1.64)0.00011.19 (0.99 to 1.43)0.0654
 1000>period243068651.53 (1.34 to 1.75)<0.00011.30 (1.13 to 1.51)0.0004
Cumulative clozapine use (days)
 Non-users2318721511
 0<period≤ 901833511.63 (1.35 to 1.96)<0.00011.48 (1.20 to 1.81)0.0002
 90<period≤180491401.09 (0.79 to 1.52)0.60570.91 (0.63 to 1.32)0.6281
 180<period≤10001785491.01 (0.85 to 1.20)0.90910.94 (0.77 to 1.14)0.5099
 1000>period68319781.08 (0.98 to 1.19)0.14561.14 (1.02 to 1.27)0.0181
Cumulative olanzapine use (days)
 Non-users2046646511
 0<period≤9039610181.23 (1.09 to 1.40)0.00121.18 (1.02 to 1.35)0.0225
 90<period≤1801563441.44 (1.18 to 1.75)0.00031.37 (1.11 to 1.70)0.0039
 180<period≤100040110381.22 (1.08 to 1.39)0.00171.15 (1.00 to 1.32)0.0561
 1000>period41213680.95 (0.85 to 1.08)0.44011.05 (0.92 to 1.19)0.4954
Cumulative quetiapine use (days)
 Non-users1669619811
 0<period≤903999671.54 (1.35 to 1.75)<0.00011.36 (1.19 to 1.57)<0.0001
 90<period≤1801473561.54 (1.26 to 1.88)<0.00011.27 (1.02 to 1.58)0.0358
 180<period≤100053411801.69 (1.50 to 1.89)<0.00011.48 (1.30 to 1.68)<0.0001
 1000>period66215321.61 (1.45 to 1.79)<0.00011.44 (1.28 to 1.62)<0.0001
Cumulative zotepine use (days)
 Non-users2292737511
 0<period≤903197431.38 (1.20 to 1.59)<0.00011.26 (1.08 to 1.47)0.0038
 90<period≤1801202651.46 (1.17 to 1.82)0.00081.27 (0.99 to 1.63)0.0592
 180<period≤10003107701.30 (1.13 to 1.49)0.00031.16 (1.00 to 1.36)0.0572
 1000>period37010801.11 (0.97 to 1.26)0.12401.00 (0.87 to 1.15)0.9854
Cumulative risperidone use (days)
 Non-users896305611
 0<period≤9039610781.26 (1.09 to 1.44)0.00121.14 (0.98 to 1.33)0.0927
 90<period≤1802075111.39 (1.16 to 1.66)0.00031.26 (1.03 to 1.53)0.0220
 180<period≤100073320281.24 (1.10 to 1.38)0.00021.12 (0.99 to 1.26)0.0845
 1000<period117935601.13 (1.03 to 1.25)0.01481.10 (0.99 to 1.23)0.0756
  • *Adjusted for diabetes mellitus, congestive heart failure, myocardial infarction, stroke, hyperlipidaemia, hypercholesterolaemia, hypertriglyceridaemia, hypertension and obesity.

  • AOR, adjusted OR; CKD chronic kidney disease; SGA, second-generation antipsychotic.