Table 2

Comparison of crude and adjusted OR for CKD among types of antipsychotics by conditional logistic regression

Drug usedCKD cases (n=3411)Controls (n=10 233)OR (95% CI)P valueAOR* (95% CI)P value
No FGA, no SGA3170.76 (0.22 to 2.59)0.65700.53 (0.13 to 2.21)0.3857
FGA alone300127811
SGA alone261021.10 (0.70 to 1.72)0.69201.06 (0.65 to 1.74)0.8068
Combination308288271.50 (1.32 to 1.71)<0.00011.28 (1.11 to 1.47)0.0009
  • *Adjusted for diabetes mellitus, congestive heart failure, myocardial infarction, stroke, hyperlipidaemia, hypercholesterolaemia, hypertriglyceridaemia, hypertension and obesity.

  • AOR, adjusted OR; CKD, chronic kidney disease; FGA, first-generation antipsychotic; SGA, second-generation antipsychotic.