Comparison of crude and adjusted OR for CKD among types of antipsychotics by conditional logistic regression
| Drug used | CKD cases (n=3411) | Controls (n=10 233) | OR (95% CI) | P value | AOR* (95% CI) | P value |
| No FGA, no SGA | 3 | 17 | 0.76 (0.22 to 2.59) | 0.6570 | 0.53 (0.13 to 2.21) | 0.3857 |
| FGA alone | 300 | 1278 | 1 | 1 | — | |
| SGA alone | 26 | 102 | 1.10 (0.70 to 1.72) | 0.6920 | 1.06 (0.65 to 1.74) | 0.8068 |
| Combination | 3082 | 8827 | 1.50 (1.32 to 1.71) | <0.0001 | 1.28 (1.11 to 1.47) | 0.0009 |
*Adjusted for diabetes mellitus, congestive heart failure, myocardial infarction, stroke, hyperlipidaemia, hypercholesterolaemia, hypertriglyceridaemia, hypertension and obesity.
AOR, adjusted OR; CKD, chronic kidney disease; FGA, first-generation antipsychotic; SGA, second-generation antipsychotic.