Table 4

Clinical outcomes measured in the MULTI sTUdy Diabetes rEsearch Consortium

Data setsAll-cause mortalityCause of deathT2DM-related events*Cardiac events*Vascular events*Liver diseaseAgeing 
diseases
Depression
T2DMRenal failure†Neuropathy‡RetinopathyCVDAnginaCADCHFMIPCI/CABGHypertensionStroke/TIA
ACCORD+++++++++++++++
AFFIRM++++++++
BARI 2D+++++++++++++
ARIC+++++++++++++++++
JHS+++++++++++++++
FHS cohort+++++++++++++++
FHS offspring++++++++++++++++
FHS Gen3++++++++++++++++
FOCUS++++++
MRFIT++++++++++++++
ALLHAT++++++++++++
BHS++++++
CORAL++++++++++++
NGHS+++
OMNI heart+++
POWER-UP++++++++++++
SPRINT-POP+++++++++
  • Ageing diseases=dementia, Alzheimer’s or Parkinson’s.

  • *All events include both fatal and non-fatal.

  • †Based on serum potassium and creatinine levels, and need for dialysis.

  • ‡Based on amputations.

  • §Only 1973–1975.

  • ACCORD, Action to Control Cardiovascular Risk in Diabetes; AFFIRM, Atrial Fibrillation Follow-Up Investigation of Rhythm Management; ALLHAT, Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial; ARIC, Atherosclerosis Risk in Communities; BARI 2D, Bypass Angioplasty Revascularization Investigation in Type 2 Diabetes; BHS, Bogalusa Heart Study; CABG, coronary artery bypass grafting; CAD, coronary artery disease; CHF, congestive heart failure; CORAL, Cardiovascular Outcomes in Renal Atherosclerotic Lesions; CVD, cardiovascular disease; FHS, Framingham Heart Study; FOCUS, Functional Outcomes in Cardiovascular Patients Undergoing Surgical Hip Fracture Repair; JHS, Jackson Heart Study; MI, myocardial infarction; MRFIT, Multiple Risk Factor Intervention Trial for the Prevention of Coronary Heart Disease; NGHS, NHLBI Growth and Health Study; OMNI heart, Optimal Macronutrient Intake Trial to Prevent Heart Disease; PCI, percutaneous coronary intervention; POWER-UP, Practice Based Opportunities for Weight Reduction Trial at the University of Pennsylvania; SPRINT-POP, Systolic Blood Pressure Intervention Trial Primary Outcome Paper; TIA, transient ischaemic attack; T2DM, type 2 diabetes mellitus.