Table 3

Cost analysis

Cost bundle categoryDescriptionTotal cost 2015 £Average cost 2015 £
PlaceboDexa-methasone(Dex-
placebo)
PlaceboDexa- methasone(Dex- placebo)
InterventionCost associated with the intervention.£12 188£14 124£1936£44£49.04£5.04
Antibiotics—cohort ACost associated with antibiotics reported in patient survey, follow-up survey and medical records.£164£138−£26£0.59£0.48−£0.11
Antibiotics—cohort BCost associated with antibiotics reported in patient survey and medical records only.£154£128−£26£0.55£0.44−£0.11
Antibiotics—societalCost associated with antibiotics inclusive of the patient copayment for prescriptions.£689£581−£108£2.49£2.02−£0.47
Antibiotics B—societalCost associated with antibiotics inclusive of the patient copayment for prescriptions for cohort B.£646£538−£108£2.33£1.87−£0.46
Antibiotics—societal for workersCost associated with antibiotics inclusive of the patient copayment for prescriptions for workers only.£623£474−£149£2.25£1.65−£0.60
Antibiotics B—societal for workersCost associated with antibiotics inclusive of the patient copayment for prescriptions for workers only in cohort B.£547£431−£116£1.98£1.50−£0.48
Over-the-counter (OTC)Cost associated with reported OTC in the patient diary and follow-up survey.£668£648−£20£2.41£2.25−£0.16
Resource use—patient diaryCost associated with resource use reported in the patient diary.£2639£2732£93£9.53£9.49−£0.04
Resource use—follow-up surveyCost associated with resource use reported in the follow-up survey.£4082£4008−£74£14.74£13.92−£0.82
Productivity losses—days 0–7 and follow-upCost of missed days due to illness reported in the patient diary and follow-up survey.£22 668£19 469−£3199£81.83£67.60−£14.23
Productivity losses (B)—days 0–7 and follow-upCost of missed days due to illness assuming all 18–21 year olds were in education.£21 505£18 634−£2871£77.63£64.70−£12.93
Productivity losses—days 1–7 and follow-upCost of missed days due to illness reported in the patient diary from day 1 and follow-up survey.£14 846£12 699−£2147£53.59£44.09−£9.50
Productivity losses (B)—days 1–7 and follow-upCost of missed days due to illness (from day 1) assuming all 18–21 year olds were in education.£14 176£12 140−£2036£51.17£42.15−£9.02
Usual activities—days 0–7 and follow-upCost associated with missing time due to illness for usual activities reported in the patient dairy and follow-up survey.£4904£5052£148£17.70£17.54−£0.16
Usual activities—days 1–7 and follow-upCost associated with missing time due to illness (from day 1) for usual activities reported in the patient dairy and follow-up survey.£3444£3672£228£12.43£12.75£0.32
Total HSP costs—primary analysis£19 073£21 002£1929£68.86£72.92£4.07
Total HSP costs—without SAE’s/AEs (n=562)
option (A)
£15 610£18 349£2739£56.76£63.93£7.17
Total HSP costs—
delayed prescription
£5830£7119.00£1289£53.99£61.90£7.91
Total HSP costs—
no delayed prescription
£13 243£13 883£640£78.36£80.25£1.89
Total HSP costs—
smokers only
(n=103)
£6059£2787−£3272£118.81£53.60−£65.21
Total SCP
option (I)
£37 076£36 409−£667£133.85£126.42−£7.43
Total SCP without SAE’s/AEs (n=562)£33 012£33 726−£667£120.04£117.51−£2.53
Total SCP—
delayed prescription
£12 995£13 816£821£120.32£120.14−£0.18
Total SCP—
no delayed prescription
£24 081£22 593−£1488£142.49£130.59−£11.90
Total SCP—
smokers only (n=103)
£8739£3259−£5480£171.35£62.68−£108.67
  • Cohort A has an additional eight patients included who reported antibiotic use in follow-up surveys only. Cohort B does not include these patients in keeping with the statistical analysis plan outlined for the clinical analysis.

  • AEs, adverse events; HSP, healthcare services payer perspective; SAE’s, serious adverse events; SCP, societal costing perspective.