Quality-adjusted life year (QALY) analysis
| Placebo (n=277*) Mean (SE) | Dexamethasone (n=288*) Mean (SE) | Difference (Dexamethasone -placebo) | P values | |
| Imputed unadjusted QALYS | 0.07165 (0.0006) | 0.07199 (0.0005) | 0.00034 (0.0009) | <0.000 |
| Imputed QALYs, adjusted for baseline differences | 0.07672 (0.0004) | 0.07677 (0.0005) | −0.00005 (0.00008) | 0.522 |
| Imputed QALYs for those given delayed prescription (adjusted) | 0.0743 (0.0005) | 0.0759 (0.0006) | 0.00155 (0.0001) | <0.000 |
| Imputed QALYs for those not given a delayed prescription (adjusted) | 0.0785 (0.0005) | 0.0770 (0.0007) | −0.00149 (0.0001) | <0.000 |
| Imputed QALYs with patients removed who experienced SAE or AE (adjusted) (n=562) | 0.0768 (0.0004) | 0.0767 (0.0005) | −0.00006 (0.00008) | 0.473 |
| Imputed QALYs with patients removed who were over 70 years (adjusted) (n=551) | 0.0766 (0.0004) | 0.0765 (0.0005) | −0.000123 (0.00008) | 0.128 |
| Imputed QALYs with patients who were current smokers only (adjusted) (n=103) | 0.0738 (0.0008) | 0.0768 (0.0010) | 0.00294 (0.00018) | <0.000 |
| Imputed QALYs at 24 hours, adjusted for baseline differences | 0.00270 (0.000008) | 0.00271 (0.000010) | 0.00001 (0.000002) | <0.000 |
| Imputed QALYs at 48 hours, adjusted for baseline differences in HRQoL | 0.00535 (0.000025) | 0.00538 (0.000031) | 0.00003 (0.000005) | <0.000 |
| Imputed QALYs at 48 hours, adjusted for baseline differences in HRQoL and RR of symptom resolution | 0.00492 (0.000024) | 0.00534 (0.000029) | 0.000422 (0.000005) | <0.000 |
*This sample size is based on 60 imputed datasets.
AE, adverse event; HRQoL, health-related quality of life; RR, relative risk; SAE, serious adverse event.