Table 3

Biomarker evaluation by receiver operator characteristics

ROC AUC (95% CI)Sensitivity (%) (95% CI)PPV (%)NPV (%)P values*
miR-122
 Gallstone versus non-gallstone†0.66 (0.59 to 0.72)16 (10 to 25)72.539.8<0.001
 Uncomplicated‡ versus complicated§0.60 (0.51 to 0.69)22 (15 to 30)56.067.50.022
cck-18
 Gallstone versus non-gallstone†0.57 (0.50 to 0.64)6 (3 to 13)50.07.10.041
 Uncomplicated‡ versus complicated§0.59 (0.50 to 0.68)14 (8 to 22)45.065.40.049
flk-18
 Gallstone versus non-gallstone†0.63 (0.56 to 0.70)20 (13 to 29)76.640.9<0.001
 Uncomplicated‡ versus complicated§0.56 (0.47 to 0.65)12 (7 to 20)42.165.00.160
  • *Kruskal-Wallis test and Dunn’s multiple comparison test.

  • †NSAP and other diseases.

  • ‡Biliary colic, aseptic choledocholithiasis.

  • §Cholecystitis, cholangitis, gallstone pancreatitis.

  • AUC, area under the curve; cck-18, caspase-cleaved keratin-18; flk-18, full-length keratin-18; miR, microRNA-122; NPV, negative predictive value; NSAP, non-specific abdominal pain; PPV, positive predictive value; ROC, receiver operating characteristic.