Table 1

Clinical outcomes and time points

Time pointData collection
BaselineDemographics, total volume of acute brain lesions, MMSE, MoCA, OCS, OKS, EQ-5D-5L, VAS and haemoglobin level.
Day 1Total volume of acute brain lesions, MMSE, MoCA, OCS, VAS and haemoglobin level.
Day 2Total volume of acute brain lesions (if not done on day 1), MMSE, MoCA, OCS, VAS and haemoglobin level (if not done on day 1).
Week 1MMSE, MoCA, OCS, VAS, OKS, EQ-5D, number of intraoperative/postoperative blood transfusions until discharge and surgical complications.
6 monthsOKS, EQ-5D and surgical complications.
12 monthsOKS, EQ-5D-5L, number of symptomatic VTEs, surgical complications, revision rate and all cause mortality.
  • Data will be obtained from next of kin and healthcare records.

  • EQ-5D-5L, five-level EuroQol-5D; MMSE, Mini-Mental State Examination; MoCA, Montreal Cognitive Assessment; OCS, Oxford Cognitive Screen; OKS, Oxford Knee Score; VAS, visual analogue scale; VTEs, venous thromboembolic events.