Data extraction template
| Publication details | First author, country of conduct, funding sources (for profit, mixed and non-profit) and year of publication. |
| Study characteristics | Study design (randomised or non-randomised), setting (single or multicentre), accrual period, length of follow-up, inclusion and exclusion criteria, Cochrane risk of bias, rates of loss to follow-up (with reasons), number of study arms, number of patients randomised per arm, number of patients analysed per arm, antifibrinolytic use during surgery (eg, aprotinin or tranexamic acid) and surgical technique (eg, endarterectomy or not, off pump or on pump, endoscopic vein harvesting or open harvesting, single or multiple vein grafts, sequential grafts, ‘no-touch’ grafting or conventional) |
| Participant characteristics | Age; proportion of women; proportion of patients with atrial fibrillation or flutter, hyperlipidaemia, prior MI, prior TIA/stroke, heart failure (NYHA functional class III–IV), diabetes mellitus, hypertension or chronic kidney disease; number of vessel grafted, left ventricular ejection fraction |
| Intervention characteristics | Dose, frequency, duration, timing for the start of treatment and adherence |
| Outcomes of Interest | Number of patients with SVGF, major bleeding, any stroke or TIA, any MI, heart failure, intracranial haemorrhage; number patients needed RBCs transfusions; number of patients admitted to hospital due to cardiovascular cause; number of deaths; number of occluded SVGs; authors’ definitions of outcomes; time and method for outcome assessments and any subgroup analyses |
MI, myocardial infarction; NYHA, New York Heart Association; RBCs, red blood cells; SVGF, saphenous vein graft failure; TIA, transient ischaemic attack.