Study purpose | Number of participants | Fraction sample | Platform | Analysed | |
Metabolomic profile | 5000 | Plasma | NMR MS | – | 150 metabolites |
Genotype | 5459 | Buffy coat | Infinium Multi-Ethnic Global (MEGAEX2) array | HiScan confocal scanner (Illumina) | 2×106 SNPs, InDels |
Whole genome sequencing | 808 | Buffy coat | Illumina TruSeq PCR free/Illumina paired-end SBS | HiSeq 4000 sequencer (Illumina) | 30× coverage |
Subexome | 200 | Buffy coat | Agilent Sureselect/Illumina paired-end SBS | MiSeq (Illumina) | Custom multigene panel 126 genes 400× coverage |
Epigenome | 150* | Whole blood | Methylation EPIC 850K array | HiScan confocal scanner (Illumina) | Differentially methylated analysis at single site and regional levels (genes, CpG island, promoters, enhancers) |
EPIC, European Prospective Investigation into Cancer and Nutrition; InDels, insertions-deletions; MS, mass spectrometry; NMR, nuclear magnetic resonance; SBS, sequencing by synthesis; SNP, single nucleotide polymorphism.
*Current acquisition.