Table 2

Incidence and HRs of AF in DM patients with or without HHS stratified by CHA2DS2-VASc score

CHA2DS2-VASc scoreNNo. of eventsPerson-yearsRate†Crude HR (95% CI)Adjusted HR (95% CI)‡
Without HHS
 113 90012386 8891.421 (Reference)1 (Reference)
 222 8653181 46 7242.171.52 (1.24 to 1.88)***1.54 (1.25 to 1.90)***
 316 6784891 07 4344.553.20 (2.62 to 3.90)***3.15 (2.58 to 3.85)***
 4856647151 2799.196.52 (5.35 to 7.95)***5.88 (4.80 to 7.19)***
 5394130920 47715.110.9 (8.84 to 13.4)***8.83 (7.11 to 11.0)***
 ≧62022193855422.616.5 (13.2 to 20.7)***10.8 (8.44 to 13.9)***
P values for trend<0.001<0.001
With HHS
 1324321031.431 (Reference)1 (Reference)
 2398927093.322.33(0.63 to 8.62)2.42(0.65 to 9.00)
 3325623632.541.72(0.43 to 6.86)1.96(0.49 to 7.88)
 4276919154.703.24(0.88 to 12.0)3.32(0.89 to 12.4)
 5150987710.37.66 (2.07 to 28.3)**8.59 (2.26 to 32.6)***
 ≥685838420.817.8 (4.70 to 67.7)***16.1 (3.79 to 68.8)***
P values for trend<0.001<0.001
  • **p<0.01; ***p<0.001.

  • †Rate per 1000 person-years.

  • ‡Adjusted for hyperlipidaemia, chronic obstructive pulmonary disease, chronic kidney disease, hyperthyroidism, sleep disorders, gout and CCI score.

  • AF, atrial fibrillation; CCI, Charlson Comorbidity Index; DM, diabetes mellitus; HHS, hyperosmolar hyperglycaemic state.