Table 2

Vital signs, resuscitation goals

Variable and treatment group	Expected number of patients	Actual number of patients	Baseline	Hours after start of therapy
Variable and treatment group	Expected number of patients	Actual number of patients	0	2	4	6
Systolic blood pressure (mm Hg)
Experimental arm	95	54	112±26	118±27	120±23	120±22
Control arm	95	49	115±29	120±24	116±23	117±23
P value			0.7	0.6	0.2	0.3
Central venous pressure (mm Hg)
Experimental arm	95	54	10±5	11±4	11±4	11±4
Control arm	95	49	9±4	10±4	10±4	10±4
P value			0.25	0.2	0.2	0.2
Heart rate (beats/min)
Experimental arm	95	54	105±25	101±23	101±24	98±24
Control arm	95	49	103±24	99±24	101±24	100±24
P value			0.6	0.7	1	0.6
Lactates (mmol/L)
Experimental arm	95	54	6.6±10	6.4±9.6	7.3±11.7	7.6±12.9
Control arm	95	49	6.3±9.0	6.1±8.5	6.3±8.8	6.8±9.2
P value			0.9	0.9	0.6	0.7
PaO₂/FiO₂(mm Hg)
Experimental arm	95	54	180±105	193±114	199±105	207±112
Control arm	95	49	196±140	193±127	193±124	194±113
P value			0.6	1	0.9	0.5
ScvO₂ (%)
Experimental arm	95	54	74.5±11	76±12	77±12	77±11
Control arm	95	49	75±11	74±13	75±11	74±10
P value			0.6	0.4	0.5	0.2
ScvO₂ <70% (%)
Experimental arm	95	54	30	21	22	24
Control arm	95	49	27	26	22	22
P value			0.8	1	0.6	0.6
Masseter-StO₂ (%)
Experimental arm	95	54	70±19	72±18	73±18	71±20
Control arm	95	49	68±22	67±24	66±26	62±28
P value			0.7	0.3	0.15	0.09
Masseter-StO₂<80% (%)
Experimental arm	95	54	62	59	51	63
Control arm	95	49	57	63	65	74
P value			0.7	0.4	0.3	0.3
Deltoid-StO₂ (%)
Experimental arm	95	54	58±25	59±26	60±25	57±26
Control arm	95	49	60±23	59±24	59±25	55±27
P value			0.7	0.9	0.8	0.7
Deltoid-StO₂ <80% (%)
Experimental arm	95	54	70	69	71	79
Control arm	95	49	77	72	74	79
P value			0.4	0.8	0.7	0.9
Thenar-StO₂ (%)
Experimental arm	95	54	83±10	83±11	81±16	81±16
Control arm	95	49	81±10	79±9	77±14	78±13
P value			0.3	0.11	0.17	0.25
Thenar-StO₂ <80% (%)
Experimental arm	95	54	31	32	26	31
Control arm	95	49	37	43	43	54
P value			0.5	0.4	0.08	0.02
StO₂ >80% over two sites (%)
Experimental arm	95	54	28	39	40	34
Control arm	95	49	29	33	36	23
P value			0.7	0.6	0.5	0.2