Factors associated with methodological quality indicators
| Items | OR and 95% CI | |||
| Crude | P value | Adjusted* | P value* | |
| Randomisation sequence generated | ||||
| English vs Chinese (ref) | 1.39 (0.64 to 3.02) | 0.41 | 1.09 (0.45 to 2.62) | 0.85 |
| Multiple vs single centre (ref) | 1.78 (0.66 to 4.75) | 0.25 | 1.63 (0.57 to 4.67) | 0.37 |
| Funding vs unclear (ref) | 1.88 (1.05 to 3.37) | 0.04 | 1.75 (0.94 to 3.26) | 0.08 |
| Sample size>76 vs ≤76 (ref) | 0.75 (0.45 to 1.23) | 0.25 | 0.73 (0.43 to 1.22) | 0.23 |
| Allocation concealment | ||||
| English vs Chinese (ref) | 4.96 (2.04 to 12.08) | <0.01 | 4.99 (1.72 to 14.47) | <0.01 |
| Multiple vs single centre (ref) | 3.02 (0.99 to 9.17) | 0.05 | 4.49 (1.39 to 14.53) | 0.01 |
| Funding vs unclear (ref) | 1.79 (0.80 to 3.99) | 0.15 | 0.98 (0.36 to 2.62) | 0.97 |
| Sample size>76 vs ≤76 (ref) | 0.53 (0.24 to 1.15) | 0.11 | 0.55 (0.24 to 1.26) | 0.16 |
| Blinding of participants and personnel | ||||
| English vs Chinese (ref) | 203.47 (24.93 to 1660.49) | <0.01 | 230.74 (19.93 to 2671.65) | <0.01 |
| Multiple vs single centre (ref) | 0.91 (0.11 to 7.35) | 0.93 | 3.81 (0.59 to 24.46) | 0.16 |
| Funding vs unclear (ref) | 3.79 (1.31 to 10.95) | 0.01 | 0.90 (0.22 to 3.74) | 0.89 |
| Sample size>76 vs ≤76 (ref) | 0.35 (0.10 to 1.15) | 0.08 | 0.80 (0.16 to 3.89) | 0.78 |
| Blinding of outcome assessors | ||||
| English vs Chinese (ref) | 50.82 (13.03 to 198.18) | <0.01 | 199.82 (22.97 to 1738.10) | <0.01 |
| Multiple vs single centre (ref) | 3.63 (0.92 to 14.32) | 0.07 | 65.47 (6.03 to 710.78) | <0.01 |
| Funding vs unclear (ref) | 2.11 (0.72 to 6.19) | 0.18 | 0.29 (0.06 to 1.49) | 0.14 |
| Sample size>76 vs ≤76 (ref) | 0.24 (0.07 to 0.87) | 0.03 | 0.24 (0.04 to 1.40) | 0.11 |
*From separate logistic regression models adjusting for other factors.
ref, reference category.