Table 1

Characteristics of 163 included trials

All trials n (%)Non-RIT trials n (%)RIT trials n (%)
Total n=163Total n=132Total n=31
Journal
New England Journal of Medicine 64 (39)53 (40)11 (35)
Lancet 63 (39)49 (367)14 (45)
JAMA 23 (14)21 (16)2 (6)
BMJ 8 (5)6 (5)2 (6)
Annals of Internal Medicine 5 (3)3 (2)2 (6)
Year*
 201112 (7)10 (8)2 (6)
 201225 (15)18 (14)7 (23)
 201334 (21)31 (23)3 (10)
 201422 (14)14 (11)8 (26)
 201543 (26)36 (27)7 (23)
 201627 (17)23 (17)4 (13)
Top specialties
 Infectious diseases(25)(24)(26)
 Haematology/Oncology(21)(17)(39)
 Cardiology(17)(19)(6)
 Pulmonary/Critical care(13)(14)(6)
 Endocrine(6)(7)(3)
Primary outcome measured as:
 Absolute risk difference114 (70)92 (70)22 (71)
 Mean26 (16)23 (17)3 (10)
 HR13 (8)9 (7)4 (13)
 Relative risk difference8 (5)7 (5)1 (3)
 OR2 (1)1 (1)1 (3)
  • Additional characteristics of the trials can be found in Aberegg et al. 15

  • *2011 and 2016 were incomplete years.

  • RIT, reduced intensity therapy.