Model input | Base case | Range | Reference |
Efficacy and safety outcome inputs | 2–6 19–22 | ||
Proportion of outcomes at 90 days in intravenous tPA group | |||
mRS 0–2 | 0.325 | 0.258–0.392 | |
Death (mRS 6) | 0.168 | 0.131–0.205 | |
sICH | 0.058 | 0.035–0.095 | |
OR at 90 days | |||
mRS 0–2 | 2.046 | 1.692–2.474 | |
Death (mRS 6) | 0.871 | 0.684–1.109 | |
sICH | 0.965 | 0.665–1.399 | |
Probabilities inputs | |||
Proportion of patients received mechanical thrombectomy | 0.861 | 0.839–0.883 | 2–6 19–22 |
Proportion of patients arrived within 4.5 hours | 0.854 | 0.839–0.869 | CNSR |
Recurrent rate of stroke (per patient year) | CNSR | ||
mRS 0–2 | 0.1026 | 0.0961–0.1093 | |
mRS 3–5 | 0.1418 | 0.1303–0.1534 | |
Relative risk of stroke recurrence per life year | 1.03 | 1.02–1.04 | 23 |
Death with recurrent stroke | 0.2101 | 0.1887–0.2316 | CNSR |
Age specific non-stroke death rate* | 0.0089–0.1653 | 25 26 | |
HR of non-stroke death for mRS 3–5 | 1.78 | 1.43–2.14 | 27 |
Cost inputs (2013 Chinese yuan renminbi) | |||
Additional costs of mechanical thrombectomy | 60 821 | 52 314–70311 | EAST |
Additional costs of intravenous tPA treatment | 11 179 | 10 555–11829 | CNSR, TIMS-CHINA |
Additional costs of sICH | 2374 | 2249–2504 | TIMS-CHINA |
One-time hospitalisation costs | CNSR | ||
mRS 0–2 | 10 055 | 9907–10205 | |
mRS 3–5 | 13 729 | 13 428–14035 | |
mRS 6 | 11 121 | 10 219–12081 | |
Annual posthospitalisation costs | CNSR | ||
mRS 0–2 | 7385 | 7156–7619 | |
mRS 3–5 | 11 350 | 10 730–11996 | |
Utility inputs | |||
mRS 0–2 | 0.76 | 0.69–0.82 | 32 |
mRS 3–5 | 0.21 | 0.17–0.26 | 32 |
Death (mRS 6) | 0 | 0.00–0.00 | 32 |
Recurrent stroke | 0.34 | 0.32–0.36 | 9 |
sICH | 0.84 | 0.72–1.0 | 31 |
Discount rate inputs | |||
Costs | 0.03 | 0.03–0.08 | 29 |
Outcomes | 0.03 | ±20% | 29 |
All costs were converted to 2013 Chinese yuan renminbi by using the medical care component of consumer price index; to convert CNY to US$, divide by 6.5.
*Age-specific non-stroke death rate: only the number of 63 years old (0.0089) and 93 years old (0.1653) are presented.
CNSR, China National Stroke Registry; EAST, Endovascular therapy for Acute ischaemic Stroke Trial; mRS, modified Rankin Scale; sICH, symptomatic intracerebral haemorrhage; TIMS-CHINA, Thrombolysis Implementation and Monitor of acute ischaemic Stroke in China; tPA, tissue plasminogen activator.