Diagnostic accuracy data reported by included studies
| Author, year | Non-TP, TP test | T+ve | F+ve | F−ve | T−ve | Total | Sensitivity (95% CI) Specificity (95% CI) | PPV (95% CI) NPV (95% CI) | Syphilis prevalence (%) |
| Benzaken et al 27 2011 | VDRL, FTA-Abs assuming missing VDRL, n=8 test +ve | 5 | 11 | 3 | 693 | 712 | 62.5% (24.5% to 91.5%) 98.4% (97.2% to 99.2%) | 31.3% (11.0% to 58.7%) 99.6% (98.7% to 99.9%) | 8/712 (1.12) |
| Assuming missing VDRL, n=6 test −ve | 4 | 12 | 2 | 694 | 712 | 66.7% (22.3% to 95.7%) 98.3% (97.0% to 99.1%) | 25.0% (7.3% to 52.4%) 99.7% (99.0% to 100.0%) | 6/812 (0.84) | |
| Bronzan et al
28 2007 Before training on how to properly obtain fingerstick blood | RPR, TPHA | 31 | 46 | 13 | 605 | 695 | 70.0% (56.0% to 0.82%) 92.9% (91.0% to 95.0%) | 40.3% (29% to 52%) 97.9% (96% to 99%) | 44/695 (6.33) |
| After training | 20 | 2 | 29 | 290 | 341 | 90.9% 90.9% | 40.8% 99.3% | 22/341 (6.5) | |
| Kashyap et al 31 2015 | VDRL, TPHA | 3 | 0 | 1 | 196 | 200 | 75.0% (95% CI NR) 100.0% | 100% 99.45% (95% CI NR) | 4/200 (2.0) |
| Montoya et al 29 2006 | RPR, TPHA | 326 | 131 | 55 | 3974 | 4486 | 86.0% (82.1% to 89.3%) 96.8% (96.2% to 97.3%) | 71.0% (66.6% to 75.1%) 98.7% (98.3% to 99.0%) | 381/4486 (8.5) |
| Tinajeros et al 30 2006 | RPR, TPPA | 314 | 128 | 28 | 8422 | 8892 | 91.8% (88.4% to 94.5%) 98.5% (98.2% to 98.8%) | 71.0% (66.6% to 75.2%) 99.7% (99.5% to 99.8%) | 342/8892 (3.8) |
F+ve, false positive; F− ve, false negative; FTA-Abs, fluorescent treponemal antibody absorbed; Non-TP, non-treponemal; NPV, negative predictive value; NR, not registered; PPV, positive predictive value; RPR, rapid plasma reagin; T+ve, true positive; T-ve, true negative; TP, treponemal; TPHA, Treponema pallidum haemagglutination test; TPPA; Treponema pallidum particle agglutination; VDRL, Venereal Disease Research Laboratory.