Epidemiological and clinical characteristics of the patients included in this study
| Characteristics | Curitiba (n=136) (%) | Fortaleza (n=427) (%) | RJ (n=32) (%) |
| Sex | |||
| Male | 61 (45) | 243 (57) | 12 (37) |
| Female | 75 (55) | 184 (43) | 20 (63) |
| Age (median, years/IQR) | 1.4 (0.5–87.9) | 1.3 (0–16.6) | 1.4 (3.3–89.3) |
| Age group (years) | |||
| <2 | 86 (63) | 254 (59) | 0 |
| 2–4 | 23 (17) | 100 (24) | 3 (9) |
| 5–17 | 11 (8) | 73 (17) | 4 (12) |
| 18–64 | 12 (9) | 0 | 9 (28) |
| >65 | 4 (3) | 0 | 16 (51) |
| Time to onset of symptoms (median, days/IQR) | 2 (0–7) | 2 (0–7) | 2 (0–6) |
| Exposure to smoking | |||
| Yes | 22 (16) | 109 (25) | 1 (3) |
| No | 90 (66) | 277 (65) | 21 (66) |
| Ex-smoker | 24 (18) | 41 (10) | 10 (31) |
| Chronic diseases* | |||
| None | 76 (56) | 341 (78) | 9 (28) |
| Cardiovascular | 16 (12) | 26 (6) | 12 (38) |
| Pulmonary | 32 (23) | 8 (2) | 7 (22) |
| Asthma | 13 (10) | 37 (9) | 9 (28) |
| Diabetes | 1 (1) | 3 (1) | 6 (19) |
| Immunosuppressed | 2 (1.5) | 9 (2) | 1 (3) |
| Renal | 0 | 7 (1.5) | 2 (6) |
| Rheumatic disease | 0 | 8 (2) | 0 |
| Cirrhosis | 0 | 2 (0.5) | 2 (6) |
| Neuromuscular | 11 (8) | 22 (5) | 0 |
| Neoplasm | 1 (1) | 1 (0.2) | 5 (16) |
| Autoimmune | 1 (1) | 8 (2) | 1 (3) |
| Length of stay in hospital (median days/IQR) | 2 (1–53) | 1 (0–14) | 2 (1–53) |
| Polypnoea | |||
| Yes | 108 (80) | 51 (12) | 17 (53) |
| No | 7 (5) | 303 (71) | 3 (9) |
| NI | 21 (15) | 73 (17) | 12 (38) |
| Use of antiviral drugs | |||
| Yes | 13 (10) | 10 (2) | 0 |
| Days of use (median/IQR) | 5 (2–5) | 15 (1–35) | – |
| Vaccination in 2014 | |||
| Yes | 42 (31) | 59 (14) | 6 (19) |
| No | 94 (69) | 344 (81) | 26 (81) |
| NI | 0 | 24 (5) | 0 |
| ICU admission | |||
| Yes | 37 (27) | 10 (2) | 26 (81) |
| No | 99 (73) | 417 (98) | 6 (19) |
| Mechanical ventilation | |||
| Yes | 29 (21.3) | 13 (3.0) | 0 |
| No | 107 (78.7) | 414 (97.0) | 0 |
| Death | |||
| Yes | 4 (3) | 4 (1) | 1 (3) |
| No | 132 (97) | 423 (99) | 31 (97) |
| Severe disease | 99 (73) | 16 (4) | 26 (81) |
↵*Some patients presented more than one comorbidity.
ICU, intensive care unit; NI, no information; RJ, Rio de Janeiro.