Table 2

Definitions of major outcomes in the CHinese Electronic health Records Research in Yinzhou (CHERRY) Study

Events of interestICD-10 code
Primary events of interest
 Death due to
  Ischaemic heart diseaseI20-I25
  Cerebrovascular diseaseI60-69
  Major cardiovascular diseaseI00-I78
  All-cause mortality
 Hospitalisation with main diagnosis of
  Myocardial infarctionI21, I22
  StrokeI60, I61, I63 (excluding I63.6), I64, H34.1
  Congestive heart failureI50
 Outpatient visit with main diagnosis of
  Hypertension*I10, I11, I12, I13, I15
  Diabetes mellitus†E10, E11, E13, E14
  Cardiovascular diseaseI00-I99
Secondary events of interest (fatal and non-fatal)
 ST-elevation myocardial infarction (STEMI)I21.0, I21.1, I21.2, I21.3, I22.0, I22.1, I22.8
 Non-ST segment elevation myocardial infarction (NSTEMI)I21.4
 Ischaemic strokeI63, I64, H34.1 (excluding I63.6)
 Haemorrhagic strokeI60, I61
 Transient ischaemic attackG45 (excluding G45.4), H34.0
 Atrial fibrillationI48
 Aortic aneurysm/aortic dissectionI71
 Peripheral artery diseaseI70.2, I73.9, I74.3, I74.4

  • *Hypertension includes either registered in the hypertension management system, or self-reported history of hypertension during health checks, or hospital admission with a diagnosis of hypertension.

  • †Diabetes mellitus includes either registered in the diabetes management system, or self-reported history of diabetes during health checks or hospital admission with a diagnosis of diabetes.

  • Majority of ICD-10 codes were selected according to the published study: ‘The Cardiovascular Health in Ambulatory Care Research Team (CANHEART): using big data to measure and improve cardiovascular health and healthcare services.’ by Tu JV, et al, 2015, Circulation: Cardiovascular Quality and Outcomes, 8, p. 208. Copyright 2015 by the American Heart Association. Adapted with permission (License Number: 4252490297412). However, codes for STEMI and NSTEMI were modified based on the study in China.34

  • ICD-10, International Classification of Diseases, tenth revision.