Table 5

Statistical significance of primary outcome changes among prospectively registered trials with inconsistent registered and published outcomes

Study characteristicN (%)P value
Positive trials
n=22		Negative trials
n=5
Impact of outcome discrepancy on statistical significance
 Newly significant published primary outcome12 (55)2 (40)0.82
 No newly significant published primary outcome6 (27)2 (40)
 Unable to determine significance of outcome change4 (18)1 (20)

  • *P=0.001.