Table 1

Eligibility criteria

Inclusion criteria

  • Male and female (non-pregnant) aged 18 years and over

  • Glomerular filtration rate >50 mL/min/1.73 m2

  • Acceptable hepatic function (alanine transaminase and aspartate transaminase levels below three times the normal range)

  • Body mass index ≤35 kg/m2

  • Non-smoker for at least 2 months

Exclusion criteria

  • Use of:

    • Antibiotics, antivirals, antiretrovirals, monoamine oxidase inhibitors, immunosuppressants, interferons and antibodies

    • Cytochrome P450 (CYP450) inducers (eg, carbamazepine, phenobarbital, phenytoin, rifampicin, St. John’s wort)

    • CYP450 inhibitors (eg, amiodarone, fluvoxamine, fluoxetine, verapamil, terbinafine).

  • Uncontrolled thyroid function

  • Presence of an important inflammatory condition

  • A diagnosed gastrointestinal pathology

  • Patients with an active cancer

  • Patients who underwent a transplant or a bariatric surgery