Table 7

Summary of GRADE evidence profile of clindamycin vs early cephalosporins

Outcome/timeframeStudy results and measurementsAbsolute effect estimatesCertainty in effect estimates
(quality of evidence)
Plain text summary
CephalosporinsClindamycin
Treatment failure/1 monthOR 0.39 (95% CI 0.11 to 1.02)
Based on data from 1572 patients in five studies
Follow-up 7–21 days
280
per 1000
109
per 1000
Moderate
Due to serious imprecision*
Clindamycin probably reduces the risk of treatment failure.
Difference: 171 fewer per 1000
(95% CI 401 fewer to 2 more)
  • *Imprecision: serious. CI includes no difference.

  • GRADE, Grading of Recommendations Assessment, Development and Evaluation.