Table 1

Key topics in the LIFEWORK baseline questionnaire and the models used to assess environmental and occupational exposures

Questionnaire
TopicItems
CharacteristicsAge, sex, marital status, country of birth, height, weight
SocioeconomicEmployment status, education
LifestyleSmoking, alcohol use, physical activity*
Housing characteristicsBedroom floor, position of the bedroom relative to the street
Residential historyFull residential history of addresses lived at for at least 12 months
Occupational historyAMIGO/EPIC-NL: full history of jobs performed for at least 6 months (job title, type of company, average number of hours per week), shift work (ever shift work and if permanent or rotating shift system)*
The Nightingale Study: full history of jobs performed for at least 6 months (job title, type of company, average number of hours per week, shift work, physical activity), shift work (rotation, frequency, calendar years), chronotype (MEQ)60*
EMF exposureCurrent and historical mobile phone use, cordless phone use and internet mobile phone use†, job tasks or use of equipment likely to lead to high EMF exposure
Health Current: physical and mental well-being (SF-12), headache (HIT-6),16 migraine (ID-migraine),17 sleep quality (MOS sleep scale),18 memory problems, hearing problems, tinnitus
Past: doctor-assessed symptoms and diseases, and age at diagnosis for conditions and events including diabetes, cardiovascular events, neurodegenerative diseases, cancer, asthma*
Reproductive health (women): parity, birth outcomes, hormone use*
Modelled exposures
Geospatial model Environmental exposures
 NISMap23 24 RF-EMF from mobile phone base stations
 ESCAPE LUR model26 27 Air pollutants (PM2.5, PM2.5 absorbance, PM10, NO2, OPdtt)
 NDVI25 Green space measure
 STAMINA28 Traffic noise exposure (eg, Lden)
 LOCATUS29 Built environment (eg, number of fast food restaurants and sport facilities in surrounding area)
Job-exposure matrix Occupational exposures
 ALOHA+JEM32 33 Dust (biological, mineral dust), pesticides (all pesticides, herbicides, insecticides, fungicides), solvents (total solvents, aromatic solvents, chlorinated solvents)
 DOM-JEM34 35 Diesel motor exhaust fumes, asbestos, chromium, nickel, PAHs, silica, animal dust, biological dust, endotoxin
 Shock-JEM36 Electric shocks at work
 ELF-MF JEM61 Extremely low-frequency magnetic fields
  • *Items differed slightly between AMIGO, EPIC-NL and the Nightingale questionnaires; more detailed information can be found in online supplementary table S1.

  • †More detailed information can be found in Schüz et al.14

  • AMIGO, Occupational and Environmental Health Cohort Study; ELF-MF, extremely low-frequency magnetic fields; EMF, electromagnetic fields; EPIC-NL, European Prospective Investigation into Cancer and Nutrition in the Netherlands; ESCAPE, European Study of Cohorts for Air Pollution Effects; HIT, Headache Impact Test; ID-migraine, identification of migraine; JEM, job-exposure matrix; Lden, day-evening-night weighted average traffic noise level for 2011; LUR, land use regression; MEQ, Morningness-Eveningness Questionnaire; MOS, Medical Outcomes Study; NDVI, Normalized Difference Vegetation Index; NO2, nitrogen dioxide; OPdtt, oxidative potential; PAH, polycyclic aromatic hydrocarbon; PM10, particulate matter with diameter ≤10 µm; RF-EMF, radiofrequency electromagnetic fields; SF, Short Form Health Survey; STAMINA, Standard Model Instrumentation for Noise Assessments.