Table 2

Inclusion and exclusion criteria for interventions

Inclusion criteriaExclusion criteria
Index case triggers a reactive intervention
  • Index case with RDT or microscopy confirmed malaria identified passively at a study health facility

  • Triggering index case resides (or stayed≥1 night within prior 4 weeks) in study enumeration area

  • Triggering index case diagnosed by active case detection

Receipt of test (rfMDA or RAVC) or control (RACD) intervention
  • Individual resides (or stayed≥1 night within prior 4 weeks) in study enumeration area within 500 m of home of triggering index case (RACD or rfMDA)

  • Household located in study enumeration area among six closest households to triggering index case household (RAVC)

  • Study intervention already implemented in individual’s household during the prior 5 weeks (RACD or rfMDA)

  • Study intervention already implemented in individual’s household during current transmission season (RAVC)

  • Household sprayed by MoHSS with DDT or deltamethrin in the past 24 hours

  • Household head refusal to participate (RAVC)

  • Individual level refusal to participate (RACD or rfMDA)

  • Refusal of RAVC is not an exclusion criterion for RACD or rfMDA.

  • Refusal of rfMDA or RACD is not an exclusion criterion for RAVC

AL administration
  • Meets above inclusion criteria for rfMDA or RACD

  • Reported pregnancy in first trimester

  • Prior regular menstruation followed by amenorrhea for most recent 4 weeks and refusal of pregnancy testing or positive pregnancy testing

  • Weight under 5 kg

  • Age under 6 months

  • Severe/complicated malaria (based on clinical assessment)

  • Prior allergy to AL

  • Personal history of cardiac dysrhythmia

  • Family history of long QT syndrome

  • Regular intake of specified QT-prolonging medications*

  • *Cardiac antiarrhythmic, neuroleptic, tricyclic antidepressant, prokinetic and antiemetic gastrointestinal, second generation antihistamine, opioid (methadone) and antimicrobial (macrolide and fluoroquinolone antibiotics, triazole antifungals) agents.

  • AL, artemether-lumefantrine; DDT, dichlorodiphenyltrichloroethane; MoHSS, Ministry of Health and Social Services; RACD, reactive case detection;  RAVC, reactive vector control; RDT, rapid diagnostic test; rfMDA, reactive focal mass drug administration.