Table 1

2×2 factorial study design showing four arms

Reactive and targeted strategies addressing human reservoir
RACD*
2 n clusters
rfMDA†
2 n clusters
Reactive and targeted strategies addressing mosquito reservoirNo RAVC
2 n clusters
RACD only arm
n clusters
rfMDA only arm
n clusters
RAVC‡
2 n clusters
RACD+RAVC arm
n clusters
rfMDA+RAVC arm
n clusters
  • *RACD: administering rapid diagnostic test to individuals living in a 500 m radius around an index case; treating positives with artemether-lumefantrine.

  • †rfMDA: presumptively treating individuals living in a 500 m radius around an index case using artemether-lumefantrine, without testing.

  • ‡RAVC: spraying long-acting insecticide Actellic 300CS to interior walls of living structures of individuals sleeping in a seven household radius around an index case.

  • RACD, reactive case detection; RAVC, reactive vector control; rfMDA, reactive focal mass drug administration.