Table 1

Timing of data collection

VariableInformation visitVisit 1
(0–1 weeks)
Visit 2
(5 weeks)
Visit 3
(17 weeks)
Visit 4
(21 weeks)
Informed consentxx
Baseline information on current illness and medical historyx
Screening blood samples*x
Start-up EMAxx
Shift to Plenadrenx
QoL questionnaire:
Fatigue Impact Scale
24 hours blood pressurexx
Blood samplesxx
Salivary cortisol (3 days)xx
Recording of adverse events, adverse reactions and the need for rescue medicationxxxx
  • *Screening blood samples corresponds to the annual biochemical assessment in pituitary patients at the Department of Endocrinology, Copenhagen University Hospital Rigshospitalet. Fasting is not necessary.

  • AddiQoL, Addison Disease-specific quality of life; DEXA, dual-energy X-ray absorptiometry; EMA, ecological momentary assessment; QoL, quality of life;  SF-36, Short Form Health Survey.