Risk factor | Study | n | Follow-up | Results (95% CI; P value) | Analysis adjusted for* |
Factors relating to the interaction between the person with dementia and their caregiver | |||||
Quality of relationship | Spruytte et al38 | 144 | 6–9 m | OR 0.92 (P=0.02) | NR |
Pruchno et al50 | 220 | 12 m | OR 1.31 (P>0.05) | a, g, s, r, t, c, bp, ADL, ci, m, hs, cb | |
Marital happiness At baseline | Wright42 | 29 | 24 m | PoV 0.313 (P<0.01) | NR |
Before dementia onset | PoV 0.045 (P>0.05) | NR | |||
Emotional closeness | Fisher and Lieberman39 | 164 | 24 m | OR 1.64 (1.09, 2.46; P=0.02) | d, ba, nf, oc, fe |
Emotional distancing/boundary ambiguity | Fisher and Lieberman39 | 164 | 24 m | OR 1.25 (0.85, 1.83; P=0.26) | d, ba, nf, oc, fe |
Wells and Over47 | 93 | 12–18 m | OR 1.3 (P>0.05) | a, d, t | |
Cohesion | Torossian and Ruffins48 | 197 | 24 m | MD NR (P>0.05) | NR |
Wright42 | 29 | 24 m | PoV 0.472 (P<0.001) | NR | |
Affection | Wright | 29 | 24 m | PoV 0.144 (P>0.05) | NR |
Warmth† | Spruytte et al38 | 144 | 6–9 m | NR (P<0.05) | NR |
Anxious-ambivalent attachment (carer) | Markiewicz et al49 | 108 | 24 m | OR 1.27 (P=0.36) | NR |
Avoidant attachment (carer) | Markiewicz et al49 | 108 | 24 m | OR 2.39 (P<0.001) | NR |
Stevens et al40 | 215 | 24 m | HR 1.011 (P=0.37) | NR | |
High levels of tension | Wright42 | 29 | 24 m | PoV 0.162 (P>0.05) | NR |
Excessive criticism*† | Spruytte et al38 | 144 | 6–9 m | NR (P>0.05) | NR |
Factors mainly relating to the caregiver | |||||
Limited adaptability | Torossian and Ruffins48 | 197 | 24 m | MD NR (P>0.05) | NR |
Approach coping | Stevens et al40 | 215 | 24 m | HR 0.997 (P=0.77) | NR |
Directing relative’s behaviour | Bannister et al45 | 116 | 12 m | MD 0.2 (P=0.40) | NR |
Keeping relative busy | Bannister et al45 | 116 | 12 m | MD 0.5 (P=0.02) | NR |
Learning about the illness | Bannister et al45 | 116 | 12 m | MD 0.3 (P=0.42) | NR |
Prioritising | Bannister et al45 | 116 | 12 m | MD 0.1 (P=0.52) | NR |
Reducing expectations | Bannister et al45 | 116 | 12 m | MD 0.4 (P=0.19) | NR |
Consistent larger sense of the illness | Bannister et al45 | 116 | 12 m | MD 0.4 (P=0.35) | NR |
Positivity | Bannister et al45 | 116 | 12 m | MD 0.5 (P=0.57) | NR |
Wells and Over47 | 93 | 12–18 m | OR 1.03 (P>0.05) | a,d | |
Seeking social support | Wells and Over47 | 93 | 12–18 m | OR 1.91 (P<0.05) | a,d |
Snyder53 | 233 | NR | HR 1.159(0.718 to 1.87; P=0.55) | a, d, g, nc | |
Accepting responsibility | Wells and Over47 | 93 | 12–18 m | OR 0.28 (P<0.01) | a, d |
Confrontational | Wells and Over47 | 93 | 12–18 m | OR 2.12 (P<0.05) | a, d |
Negative feelings | Fisher and Lieberman39 | 164 | 24 m | OR 1.47 (0.99 to 2.19; P=0.05) | d, ba, oc, ec, fe |
*Prespecified key confounders: a, age; d, dementia severity; g, gender; s, socioeconomic status. All other confounders: ADL, activities of daily living; ba, boundary ambiguity; bp, behaviour problems; c, number of children; cb, caregiver burden; ci, caregiver illness; ec, emotional closeness; fe, family efficiency; hs, help services used; m, medication; nc, non-coresidency; nf, negative feeling; oc, organised cohesiveness; r, religion; t, time spent (duration of) caregiving.
†These are the subscales of the relationship quality scale.
HR > 1 indicates increased risk, HR < 1 indicates decreased risk. OR > 1 indicates increased odds of outcome, OR < 1 indicates decreased odds of outcome.
Corr, correlation (This is a number between −1 to +1 and indicates the degree to which the exposure and outcome vary together. Positive numbers indicate that exposure and outcome increase together, while negative numbers indicate that the outcome increases as the exposure decreases. Larger numbers indicate stronger correlation); MD, mean difference in outcome (Large differences between groups suggests that the exposure might affect the outcome. For continuous exposures, mean difference represents the change in the outcome for one unit increase in the exposure.); NR, information not reported (where possible results and 95% CIs were calculated from raw data); PoV, proportion of variance (This is a number between 0–1 indicating the proportion of variance in the outcome explained by the exposure. Higher numbers indicate greater explanatory power of the exposure.)