Table 3

Mixed effects final longitudinal models

VariableParameterModel
ValueSEdft Valuep ValueAICBIClogLik
Case–control series
Linear model
 Status addicted0.38140.11211183.40250.00091046.2321077.646−516.1161
 Age:status addicted−0.00620.0026118−2.39910.0180
 Days0.00010.00001182.30230.0231
 Age:days0.00000.0000118−2.26750.0252
Quadratic model
 Status addicted0.17980.04971133.61760.00041077.5821131.343−526.7911
 (Age)2:days:status addicted−0.00170.0005113−3.15490.0021
 Age:days:status addicted0.00260.00091132.82830.0055
 Days:status addicted−0.00010.0000113−2.73440.0073
 Age:status addicted−2.35280.8716113−2.69950.0080
 Age:days−0.00090.0004113−2.51020.0135
 Days0.00000.00001132.17060.0321
All patients
 Status addicted0.42530.05885147.23530.00002737.4662776.991−1361.733
 Age:status addicted−0.00720.0015514−4.80600.0000
 Days:status addicted−0.00030.0001514−4.75780.0000
 Age:days0.00000.00005143.72690.0002
All patients including sex
 Status addicted0.34960.06375125.49130.00002745.2712796.080−1363.636
 Age:status addicted−0.00720.0015512−4.78190.0000
 Age:days:status addicted0.00000.0000512−4.41020.0000
 Sex man:status addicted0.11270.02895123.90090.0001
 Age:days0.00000.00005123.64540.0003
Men
 Age:status addicted−0.00840.0018317−4.67260.00001809.9221851.731−896.9608
 Status addicted0.45600.11243174.05540.0001
 Days:status control0.00020.00013172.76060.0061
 Days:status addicted−0.00010.0001317−2.71250.0070
Women
 Age:days:status addicted0.00000.0000193−3.35980.0009984.1011011.518−486.0503
 Status addicted0.10270.03811932.69840.0076
 Age:days0.00000.00001932.50550.0131
All patients including biochemistry
 ALT:status addicted0.10220.01914425.35060.00002641.7882703.304−1309.894
 Age:ALT:status addicted−0.00180.0004442−4.43200.0000
 Age:days:ALT:globulin:status addicted0.00000.0000442−3.33500.0009
 Age:days:ALT:globulin:Status control0.00000.00004422.88710.0041
 ALT:globulin:status control−0.01070.0050442−2.13450.0334
Males with biochemistry
 ALT:status addicted0.10220.02092814.87790.00001862.0391924.291−919.0196
 Age:ALT:status addicted−0.00200.0005281−4.33980.0000
 Days:ALT:status addicted−0.00010.0000281−3.99030.0001
 Days:ALT0.00010.00002812.82970.0050
 Age:days:ALT:globulin0.00000.0000281−2.37870.0180
 Days:ALT:globulin0.00030.00012812.31900.0211
 Age:days:globulin0.00000.00002812.30060.0221
 Days:globulin−0.00100.0005281−2.20990.0279
Females with biochemistry
 Globulin:status addicted0.21580.06691503.22460.0015979.5081037.669−476.754
 Age:globulin:status addicted−0.00760.0024150−3.13750.0021
 Age:dd:ALT:globulin:status addicted0.00000.0000150−2.97720.0034
 ALT:globulin−0.03940.0139150−2.83850.0052
 Age:ALT:globulin:status addicted0.00160.00061502.83390.0052
 Age:days:ALT0.00000.00001502.50960.0132
 Age:days0.00000.0000150−2.34260.0205
  • AIC, Akaike Information Criterion; ALT, alanine aminotransferase; BIC, Bayesian Information Crieterion; DD, days; logLik, Log Likelihood ratio.