The relationship between HPTN 068 trial participation and school enrolment in 2011 and 2015, stratified by age, in the full cohort and the cohort restricted to those enrolled in school in 2011
| Enrolment | n | Per cent enrolled | RD (95% CI) | aRD* (95% CI) | |
| 2011: full cohort | |||||
| All ages | |||||
| Trial participant | 1637 | 1651 | 99.2 (98.7, 99.6) | 6.3 (5.1 to 7.5) | 2.9 (−0.7 to 6.5) |
| Non-trial participant | 1871 | 2015 | 92.9 (91.7, 94.0) | 1 | 1 |
| Ages 11–15 | |||||
| Trial participant | 1036 | 1038 | 99.8 (99.5, 1.00) | 0.6 (0.0 to 1.2) | 0.4 (−5.2 to 5.9) |
| Non-trial participant | 1115 | 1124 | 99.2 (98.6, 99.7) | 1 | 1 |
| Ages 16–17 | |||||
| Trial participant | 532 | 539 | 98.7 (97.8, 99.7) | 6.9 (4.6 to 9.2) | 6.3 (0.5 to 12.2) |
| Non-trial participant | 593 | 646 | 91.8 (89.7, 93.9) | 1 | 1 |
| Ages 18–20 | |||||
| Trial participant | 69 | 74 | 93.2 (87.5, 99.0) | 26.7 (18.5 to 34.9) | 19.5 (5.6 to 33.3) |
| Non-trial participant | 163 | 245 | 66.5 (60.6, 72.4) | 1 | 1 |
| 2015: full cohort | |||||
| All ages | |||||
| Trial participant | 1234 | 1524 | 81.0 (79.0, 83.0) | 12.5 (9.6 to 15.4) | 6.8 (3.4 to 10.2) |
| Non-trial participant | 1231 | 1797 | 68.5 (66.4, 70.7) | 1 | 1 |
| Ages 11–15 | |||||
| Trial participant | 837 | 952 | 87.9 (85.9, 90.0) | 3.8 (0.1 to 6.9) | 1.9 (− 1.3 to 5.0) |
| Non-trial participant | 833 | 990 | 84.1 (81.9, 86.5) | 1 | 1 |
| Ages 16–17 | |||||
| Trial participant | 361 | 503 | 71.8 (67.9, 75.8) | 12.5 (6.9 to 18.1) | 12.7 (6.7 to 18.7) |
| Non-trial participant | 346 | 584 | 59.3 (55.4, 63.4) | 1 | 1 |
| Ages 18–20 | |||||
| Trial participant | 36 | 69 | 52.2 (41.6, 65.4) | 28.9 (15.8 to 41.9) | 29.7 (16.1 to 43.3) |
| Non-trial participant | 52 | 223 | 23.3 (18.4, 29.6) | 1 | 1 |
| 2015: restricted cohort† | |||||
| All ages | |||||
| Trial participant | 1234 | 1510 | 81.7 (79.8, 83.7) | 7.3 (4.5 to 10.2) | 4.9 (1.5 to 8.3) |
| Non-trial participant | 1231 | 1655 | 74.4 (72.3, 76.5) | 1 | 1 |
| Ages 11–15 | |||||
| Trial participant | 837 | 950 | 88.1 (86.1, 90.2) | 3.2 (0.2 to 6.3) | 1.8 (−1.3 to 5.0) |
| Non-trial participant | 833 | 982 | 84.8 (82.6, 87.1) | 1 | 1 |
| Ages 16–17 | |||||
| Trial participant | 361 | 496 | 72.8 (69.0, 76.8) | 7.6 (1.9 to 13.3) | 7.9 (1.9 to 14.0) |
| Non-trial participant | 346 | 531 | 65.2 (61.2, 69.3) | 1 | 1 |
| Ages 18–20 | |||||
| Trial participant | 36 | 64 | 56.3 (45.3, 69.8) | 19.6 (5.1 to 34.1) | 22.8 (7.3 to 38.2) |
| Non-trial participant | 52 | 142 | 36.6 (29.5, 45.5) | 1 | 1 |
↵*Adjusted for socioeconomic status (coded dichotomously at median household asset index score), country of origin (South African vs Mozambican), educational attainment of household head (coded dichotomously at grade 12 attainment), gender of household head (male vs female), household size (coded linearly) and pre-2011 childbearing (yes vs no). Models that are not age-stratified are also adjusted for age coded in 2-year categories.
↵†Restricted to all young women who were enrolled in school in 2011.
aRD, adjusted risk difference; HPTN, HIV Prevention Trial Network; RD, risk difference.