| Cancer death (a subset of non-CVD death) | |||
| Events, n | 1226 | 475 | 751 |
| Crude | 1.27 (1.09 to 1.53) | 1.53 (1.11 to 2.12) | 1.06 (0.87 to 1.29) |
| Model 1* | 1.29 (1.09 to 1.53) | 1.45 (1.04 to 2.01) | 1.16 (0.95 to 1.42) |
| Model 2† | 1.25 (1.05 to 1.48) | 1.40 (1.01 to1.95) | 1.14 (0.93 to 1.40) |
| Model 3‡ | 1.20 (1.01 to 1.43) | 1.35 (0.97 to 1.88) | 1.11 (0.91 to 1.36) |
| Model 4§ | 1.16 (0.96 to 1.39) | 1.37 (0.97 to 1.92) | 1.08 (0.87 to 1.33) |
| Model 5¶ | 1.15 (0.96 to 1.38) | 1.36 (0.97 to 1.91) | 1.08 (0.90 to 1.34) |
| Model 4 + CES-D × self-reported health | P value for the interaction term — 0.20 | ||
End of follow-up is 31 December 2012. Bold P value<0.05; missing data in covariates imputed using chained equations.
*Model 1 adjusts for sociodemographics (age, gender, region, income, health insurance and education).
†Model 2 adds to model 1 medical conditions, physiological factors and medication use (systolic blood pressure, total cholesterol, high-density lipoprotein–cholesterol, use of aspirin, statins, antihypertensives, antidepressants, body mass index, logarithmically transformed albumin to creatinine ratio, diabetes, CVD, medication use as a proxy for chronic obstructive pulmonary disease and cognitive impairment).
‡Model 3 adds to model 2 behavioural risk factors (pack-years of cigarette smoking, self-reported alcohol use, physical inactivity and medication non-adherence).
§Model 4 adds to model 3 other factors (physical health component score of SF-12, log-transformed high sensitivity C reactive protein and perceived stress).
↵¶Model 5 adds non-fatal CVD event—first non-fatal myocardial infarction or stroke since baseline.
CES-D, Centre for Epidemiology Studies Depression; CVD, cardiovascular disease; SF-12, Short-Form Health Survey.